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6 rezultatus
Proline or proline derivatives for the treatment of dementia
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Prisijungti Registracija
The invention relates to pharmaceutical composition comprising proline derivatives, preferably Cis-4-hydroxy-I-proline (CHP) and trans-4-Hydroxy-L-proline (THP), or proline, or their salts, esters, isomers, racemates, enantiomers or pro-drugs thereof, and to the use of said compositions for the
Proline derivatives possessing prolyl endopeptidase-inhibitory activity
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Prisijungti Registracija
FIELD OF THE INVENTION
The present invention relates to novel praline derivatives possessing prolyl endopeptidase-inhibitory activities, method of production thereof and pharmaceutical use thereof.
BACKGROUND OF THE INVENTION
Along with the arrival of an aging society, the medical treatment of
Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors
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Prisijungti Registracija
SUMMARY OF THE INVENTION
The compounds of the present invention are antagonists of the VLA-4 integrin ("very late antigen-4"; CD49d/CD29; or .alpha..sub.4.beta..sub.1), the .alpha..sub.4.beta..sub.7 integrin (LPAM-1 and .alpha..sub.4.beta..sub.p), and/or the .alpha..sub.9.beta..sub.1 integrin, and
Substituted prolines / piperidines as orexin receptor antagonists
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Prisijungti Registracija
BACKGROUND
Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus
Substituted prolines/piperidines as orexin receptor antagonists
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
BACKGROUND
Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus
Substituted prolines/piperidines as orexin receptor antagonists
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
BACKGROUND
Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus
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