Participants enrolled into this arm will only receive educational materials, but will not receive specific recommendations to make changes to the medications they are taking.
Cognitive testing at the beginning and the end of the study will be done with and without a scopolamine patch to reveal cognitive reserve.

Participants enrolled into this arm will receive educational materials and will have their medications assessed; recommendations for changes in the medications taken will be made when appropriate.
Cognitive testing at the beginning and the end of the study will be done with and without a scopolamine patch to reveal cognitive reserve.

Alzheimer's Disease

Dementia

Participants will receive educational materials, but will not receive MTM.

Placebo

Participants will receive MTM in addition to the educational materials.

Medication Therapy Management (MTM)

At the beginning and end of the study, participants will be asked to use a scopolamine patch. This patch is not being used to prevent motion sickness (as approved by the FDA), but instead is being used to challenge the participant's memory and thinking abilities and determine cognitive reserve.

Scopolamine patch

University of Kentucky

The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression

INtervention for Cognitive Reserve Enhancement in Delaying the Onset of Alzheimer's Symptomatic Expression: The INCREASE Study

change from baseline to end of study for Trail Making Test B

change from baseline to end of study for Montreal Cognitive Assessment

change from baseline to end of study for California Verbal Learning test

change from baseline to end of study for Short Form Health Survey (SF-36)

Daniela Moga

Sponsor/PI

National Institute on Aging (NIA)

Scopolamine

The Use of EEG in Alzheimer's Disease, With and Without Scopolamine - A Pilot Study

Development of a Diagnostic Tool for Alzheimer's Disease

The EEG is recorded before, during and after scopolamine administration in order to monitor the effects scopolamine has on the brain as measured by EEG.

Mentis Cura

Landspitali University Hospital

Observational Study

Lifespan

Detection of Disease-Related Changes in Pre-Symptomatic Alzheimer's Disease

Total number of correct moves over 5 trials on the Groton Maze Learning Test at 3 hours

Mean number of correct moves per second on the Groton Maze Learning Test at 3 hours

An informational exercise to provide further information about amyloid PET imaging and to determine the impact of this disclosure of study participants.

A functional activity of daily living where study participants are given pre-determined destinations / conditions and asked to map the route. Main outcome measure for this assessment is time taken to solve the problem.

A six-item scale measuring age-related memory decline. An overall index of cognitive decline is calculated by summing scores for all six items with double weighting for item #6. Higher scores indicate greater decline in memory.

dementia/skopolaminas

The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression

The Use of EEG in Alzheimer's Disease, With and Without Scopolamine - A Pilot Study

Detection of Disease-Related Changes in Pre-Symptomatic Alzheimer's Disease

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