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Nonsteroidal anti-inflammatory drugs in early pregnancy.

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A study was performed of congenital malformations in infants whose mothers used nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy. Data were obtained from an ongoing prospective recording of drug use during the first trimester. During the period July 1, 1995 through December 31, 1998,

Early treatment of asthma.

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The early treatment of asthma was not greatly studied before the 1990s. Subjects included in intervention trials have usually had persistent asthma with a long duration of symptoms. Only a few studies have been done on early intervention. It has also become obvious that eosinophilic airway

Anti-inflammatory treatment increases angiogenesis during early fracture healing.

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OBJECTIVE Both inflammation and angiogenesis are crucial for normal fracture healing. The goal of this work was to determine how anti-inflammatory treatment affects angiogenesis during early stages of fracture repair. METHODS Tibia fractures were created in adult mice and animals were treated with

Anti-inflammatory cytokine profile in early human tendon repair.

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OBJECTIVE The aim of this study was to assess inflammation and the presence and relative levels of cytokines, which may be involved in regulating early human Achilles tendon healing. METHODS Nine patients with acute Achilles tendon rupture were included, operated on and post-operatively immobilized.

Early Antiinflammatory Therapy Attenuates Brain Damage After Sah in Rats.

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Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying

Repositioning Chromones for Early Anti-inflammatory Treatment of COVID-19

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The COVID-19 pandemic is posing an unprecedented sanitary threat. In the absence of specific vaccines and anti-SARS-CoV-2 drugs, medicines that may assist in tackling the emergency and limiting the high number of fatalities are urgently needed. The repositioning of available drugs to treat COVID-19

Benefits of early anti-inflammatory medication following acute ankle injury.

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A total of 122 patients presenting with acute ankle injuries within 6 h of injury were entered into a double-blind study. Treatment consisted of a standardized regimen of physiotherapy and elastic support for all patients, who were then randomized into two groups. One group received immediate

Are early arthritis clinics necessary?

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Landmark studies published in the 1980s were the first to reveal the long-term consequences of rheumatoid arthritis (RA). Instead of the benign outcomes previously reported from early population studies, disability, deformity and excess mortality were evident. At this time, the conventional pyramid

[Early clinical experiments with a new synthetic anti-inflammatory agent].

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Management of early rheumatoid arthritis.

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Rheumatoid arthritis is a treatable cause of disability. The benefits of disease modifying anti-rheumatic drug therapy (DMARD) have been established, and current best practice is to commence it as early as possible during the course of RA. Equally, important is to monitor treatment effects, and

[The treatment of early asthma].

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Asthma is an inflammatory disease of the bronchial mucosa associated with pulmonary function disorders of varying degrees of severity. The early detection of eosinophil-related mucosal inflammation constitutes both a diagnostic challenge and the key to treatment that may markedly improve outcome.

Can early therapy reduce inflammation?

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OBJECTIVE Serious non-AIDS events or noninfectious complications of HIV infection far outnumber AIDS events in the current combination antiretroviral therapy (ART) era and are attributed to chronic inflammation. Thus, a better understanding of why inflammation persists on ART will assist in

Rheumatoid arthritis: early treatment with corticosteroids and nonsteroidal anti-inflammatory drugs.

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The family physician plays several important roles in the management of patients with RA by early diagnosis of RA, with initiation of synthetic DMARD therapy, and in long-term follow-up to minimize complications of DMARD therapy and its impact on patient comorbidities. Three recently approved

[Anti-inflammatory cytokine in early diagnosis of endometritis after Cesarean section].

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Antiinflammatory cytokines IL-1 alpha, IL-1 beta, IL-8, and TNF-alpha are measured and clinical course of the postoperative period is analyzed in 30 women after cesarean section. Postoperative endometritis can be predicted from an increase in the concentrations of IL-8 and TNF-alpha on days 2-3

Hydrocortisone Suppresses Early Paraneoplastic Inflammation And Angiogenesis To Attenuate Early Hepatocellular Carcinoma Progression In Rats.

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Inflammation is implicated in both hepatic cirrhosis development and hepatocellular carcinogenesis, and treatment with long-acting glucocorticoid dexamethasone prevented liver carcinogenesis in mice. However, it is unclear whether glucocorticoids have anti-inflammatory effect on

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