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Puslapis 1 nuo 1904 rezultatus
Nutritional effects of field-bean (Vicia faba L.) protease inhibitors and field beans fed to rats [proceedings].
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Clinical application of plant protease (Kimotab) in the surgical field.
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The death of plant cells: from proteases to field applications.
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Bacterial extracellular protease activities in field soils under different fertilizer managements.
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The major extracellular endopeptidase from Bacillus subtilis PF212 (isolated from paddy field soil) and B. subtilis CF80 (isolated from upland field soil) belongs to the group of serine proteases produced by Bacillus spp. known as subtilisins (optimum pH 7.0, optimum temperature 60 degrees C, and
Electric fields in active sites: substrate switching from null to strong fields in thiol- and selenol-subtilisins.
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Although known to be important factors in promoting catalysis, electric field effects in enzyme active sites are difficult to characterize from an experimental standpoint. Among optical probes of electric fields, Raman spectroscopy has the advantage of being able to distinguish electronic
FILO (field interaction ligand optimization): a simplex strategy for searching the optimal ligand interaction field in drug design.
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A method (FILO, Field Interaction Ligand Optimization) for obtaining the optimal molecular interaction field was developed on the basis of the Simplex optimization procedure applied to a matrix of interaction energies obtained by performing a GRID computation on a suitable data set. The FILO
Accurate Calculation of Electric Fields Inside Enzymes.
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The specific electric field generated by a protease at its active site is considered as an important source of the catalytic power. Accurate calculation of electric field at the active site of an enzyme has both fundamental and practical importance. Measuring site-specific changes of electric field
Inhibition of benzopyrene-induced forestomach tumors by field bean protease inhibitor(s).
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Protease inhibitors (PIs), particularly the soybean-derived Bowman-Birk inhibitor, have proved to be powerful blockers of carcinogenesis in many in vitro and animal model systems. However, so far an ability of PIs to suppress gastric carcinogenesis has not been demonstrated, because of the
The emerging field of HCV drug resistance.
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BACKGROUND
With 170 million people infected worldwide and an inadequate current standard of care, hepatitis C virus (HCV) infection represents a major unmet medical need. Multiple companies are working on the discovery and development of specific HCV antiviral drugs, including inhibitors of HCV
[Studies in the field of hydrolytic enzymes].
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A study in the properties of hydrolytic enzymes and the processes of hydrolysis relized by them is a main trend in the department activity. Special attention is paid to the studies in hydrolases of microbial origin. Methods are developed for obtaining the proteolytic and cellulolytic complexes
Static magnetic field effects on proteases with fibrinolytic activity produced by Mucor subtilissimus.
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The influence of a static magnetic field (SMF) on crude enzyme extracts with proteolytic activity is described and discussed. Proteolytic enzymes, which hydrolyze peptide bonds, and fibrinolytic enzymes, which dissolve fibrin clots, have industrial relevance, and applicability dependent on
Comparative molecular field analysis of a series of inhibitors of HIV-1 protease.
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Several protease inhibitors have reached the world market in the last fifteen years, dramatically improving the quality of life and life expectancy of millions of HIV-infected patients. In spite of the tremendous research efforts in this area, resistant HIV-1 variants are constantly decreasing the
99mTc-labeled field bean protease inhibitor can function as an efficient tumor detecting agent.
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Purified field bean protease inhibitor (FBPI) was labeled with 99mTcO4- to ascertain its ability to locate tumors in tumor-bearing rat models. The labeling was done with Sn2+ as a reducing agent and the yield was 95%. It was stable for 2 hr at ambient temperature. The biodistribution study of the
Reduction of protease activity in milk by continuous flow high-intensity pulsed electric field treatments.
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High-intensity pulsed electric field (HIPEF) is a non-thermal food processing technology that is currently being investigated to inactivate microorganisms and certain enzymes, involving a limited increase of food temperature. Promising results have been obtained on the inactivation of microbial
Field bean protease inhibitor preparations, unlike methotrexate, can completely suppress Yoshida sarcoma tumor in rats.
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Protease inhibitor preparations (PIP) with antitryptic and antichymotryptic activities, isolated from field bean legume as well as doxorubicin and cyclophosphamide could effectively suppress the growth of Yoshida sarcoma ascites tumor cells transplanted in adult rats and prevent their death. As
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