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Substituted-indole-compounds as estrogen receptor down-regulators

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Prisijungti Registracija

FIELD OF INVENTION The present invention relates to a novel class of indole derivatives, particularly a compound represented by formula (I), a preparation method, a pharmaceutical composition and a use as estrogen receptor down-regulator in preparing a medicament for treating estrogen

2,3-dihydro-1H-indole compounds

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The present invention relates to novel 2,3-dihydro-1H-indole compounds that inhibit the conversion of tryptophan to kynurenine, certain of which have been confirmed to bind to indoleamine 2,3-dioxygenase (IDO1). The present invention also relates to pharmaceutical compositions comprising these

Inhibitor of breast cancer resistance protein (BCRP)

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Prisijungti Registracija

BACKGROUND Resistance to anticancer agents is a major cause of chemotherapeutic failure in cancer. (M. K. Rosenberg et al., Structure, 2010, 18, 482.) The 75 kDa human breast cancer resistance protein (BCRP) is a polytopic plasma membrane transport protein that has been detected in many

Breast cancer cell growth-inhibiting enzyme inhibitors, method for the production thereof, and use thereof

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BACKGROUND OF THE INVENTION According to epidemiological data, breast cancer is the most frequent form of cancer in women [1]. Particularly aggressive breast cancers are characterized by invasive and metastatic behavior [2]. The treatment of such aggressive breast cancers is extremely problematic

Indole derivatives

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This application is a 371 of PCT/SP93/0056 filed Apr. 28, 1993. TECHNICAL FIELD The present invention relates to novel indole derivatives. PRIOR ART The indole derivatives of the invention are novel compounds not yet described in the literature. DISCLOSURE OF INVENTION It is an object of the

2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents

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The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds. BACKGROUND OF THE INVENTION The use of hormone replacement therapy for bone

Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process

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Prisijungti Registracija

CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a national phase entry under 35 U.S.C. .sctn.371 of International Application No. PCT/FR2004/002261 filed Sep. 6, 2004, published in France, which claims priority from French Patent Application No. 0310460 filed Sep. 4, 2003 and

Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-.alpha. modulators

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Prisijungti Registracija

FIELD OF THE INVENTION The present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and for treating conditions such as cancer, arthritis, inflammatory airway disease, and metabolic disorders. More particularly, the

17.beta.HSD type 5 inhibitor

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TECHNICAL FIELD The present invention relates to an indole compound having a pharmacological activity and a pharmaceutically acceptable salt thereof. The present invention also relates to a medicament or a pharmaceutical composition containing the indole compound or a pharmaceutically acceptable

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