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Puslapis 1 nuo 21 rezultatus
Comments on the relations between auditory fatigue and iris pigmentation.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
It has been reported that subjects with highly pigmented irises (brown) experience significantly less temporary threshold shift (TTS) than subjects with less pigmented irises (blue), and that those with green-gray pigmentation display intermediate amounts of TTS. TOTA and BOCCI noted the high
IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
OBJECTIVE
Irosustat is a first-generation, orally active, irreversible steroid sulfatase inhibitor. We performed a multicentre, open label phase II trial of the addition of Irosustat to a first-line aromatase inhibitor (AI) in patients with advanced BC to evaluate the safety of the combination and
Phase I study of irinotecan and cisplatin in combination with pelvic radiotherapy in the treatment of locally advanced cervical cancer: A GINECO trial.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
OBJECTIVE
To define the recommended dose of the association of weekly irinotecan (Iri) and cisplatin (CP) with pelvic radiotherapy in Locally Advanced Cervical Cancer.
METHODS
Stage IB2-IV cervix cancer patients were treated with escalating doses of Iri starting from 30 mg/m(2) and a fixed dose of
Nanoliposomal irinotecan with fluorouracil for the treatment of advanced pancreatic cancer, a single institution experience.
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Prisijungti Registracija
BACKGROUND
Effective treatment options for advanced pancreatic cancer are finite. NAPOLI-1, a phase III randomized trial, demonstrated the efficacy of nanoliposomal irinotecan with fluorouracil/leucovorin (nal-IRI + 5-FU/LV) for the treatment of advanced pancreatic cancer following progression on
Phase II study of S-1-based sequential combination chemotherapy including oxaliplatin plus bevacizumab and irinotecan with or without cetuximab for metastatic colorectal cancer: the SOBIC trial.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
Experience with S-1 in older Caucasian patients with metastatic colorectal cancer (mCRC): Findings from an observational chart review.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
BACKGROUND
An aging population will increase the number of older patients with metastatic colorectal cancer (mCRC). However, there is limited knowledge about treatment in older patients as they are under-represented in clinical trials. The oral fluoropyrimidine S-1 is associated with a lower rate of
Quality of life in metastatic pancreatic cancer patients receiving liposomal irinotecan plus 5-fluorouracil and leucovorin.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
BACKGROUND
The NAPOLI-1 study (NCT01494506) reported that liposomal irinotecan plus 5-fluorouracil and leucovorin (nal-IRI+5-FU/LV) improved overall survival vs 5-FU/LV with manageable toxicity in patients with metastatic pancreatic adenocarcinoma previously treated with gemcitabine-based therapy.
A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
Preclinical activity of irinotecan has been seen in glioma models, but only modest efficacy has been noted in clinical studies, perhaps related to drug distribution and/or pharmacokinetic limitations. In preclinical testing, irinotecan liposome injection (nal-IRI) results in prolongation of drug
[Successful treatment of recurrent hypoglycemia by pioglitazone in a patient with myotonic dystrophy].
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Prisijungti Registracija
A 20 year-old woman with myotonic dystrophy type 1 (DM1) presented with fatigue, daytime somnolence, and sudden poor responsiveness. Blood glucose was measured before and after each meal for 4 days, and hypoglycemia was confirmed twice, although neither perspiration nor palpitations occurred in the
The influence of eye colour upon temporary threshold shift.
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Prisijungti Registracija
Controversy has arisen over the claim that melanin content of the iris as determined by eye colouration bears a direct relationship to susceptibility to temporary threshold shifts (TTS). A more comprehensive investigation of TTS has now been carried out which not only confirms the relationship but
[A Case of Pneumocystin a Patient with Pneumonia That Developed during Chemotherapy for Sigmoid Cancer].
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A 63-year-old man was diagnosed with advanced sigmoid cancer of pT3, pN0, sM1c, sP3, fStage Ⅳ post-operation. After CAPOX plus Bmab as the first-line chemotherapy, he underwent IRIS plus Bmab as the second-line chemotherapy. After 1 course of IRIS plus Bmab, he was admitted to the hospital for
Phase I dose escalation study of gemcitabine plus irinotecan in advanced solid tumors.
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
OBJECTIVE
To determine the maximally tolerated dose (MTD), recommended phase II dose (RPTD) and toxicity profile of gemcitabine plus irinotecan combination.
METHODS
Thirty-nine evaluable patients with advanced solid tumors were treated with gemcitabine (Gem) and irinotecan (Iri) on days 1, 8 and 15
[A case of unresectable advanced gastric cancer successfully treated with continuous S-1 + CPT-11 chemotherapy accompanied by dose reduction against grade 4 hematological adverse event].
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
We report a successful case of chemotherapy accompanied with grade 4 adverse events for unresectable advanced gastric cancer. A 73-year-old man was admitted to our hospital with complaint of abdominal pain in July 2007. The detailed examination had revealed advanced gastric cancer, lymph node
New glaucoma medications in the geriatric population: efficacy and safety.
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Prisijungti Registracija
Glaucoma can be considered a disease of the aging eye. Most medications used to treat glaucoma are in topical eyedrop form and may cause numerous untoward systemic effects in older persons. In recent years, several new ocular hypotensive medications have become available. These medications are being
[Near triad measurement--accommodative pupillometry with horizontal eye tracking and its qualitative analysis].
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
OBJECTIVE
Recording of "near triad responses" was done by static accommodative stimulation to reveal the qualitative analysis of asthenopia.
METHODS
Twelve healthy subjects in agegroups of 20, 30, and 40 years were examined before and after several hours of visual display terminal (VDT) work after
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