isopropanol/uždegimas

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Effects of isopropanol on the development of inflammatory reactions in rats.

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The effects of isopropanol on the development of inflammation were studied in rats. Isopropanol inhibited both the histamine-induced increase in cutaneous vascular permeability and the carrageenan-induced plasma exudation into the pleural cavity. The lipopolysaccharide-induced leucocyte emigration

Changes in rat liver metallothionein and metallothionein mRNA induced by isopropanol.

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Administration of isopropanol (1 ml/kg body weight) via the ip route significantly depressed the serum zinc concentration within 8 hr. A maximal increase in hepatic metallothionein was observed 16 hr after isopropanol. By 48 hr after treatment metallothionein levels in liver had returned to basal

The dysregulation of the monocyte/macrophage effector function induced by isopropanol is mediated by the defective activation of distinct members of the AP-1 family of transcription factors.

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Isopropanol is the second most common cause of short-chain alcohol acute intoxication. Nonethanolic short-chain alcohols mediate their immunomodulatory effect by interfering with nuclear factor of activated T cells (NFAT) activation with or without additional activator protein-1 (AP-1) involvement.

Solid-phase microextraction based on an agarose-chitosan-multiwalled carbon nanotube composite film combined with HPLC-UV for the determination of nonsteroidal anti-inflammatory drugs in aqueous samples.

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We describe the preparation, characterization, and application of a composite film adsorbent based on blended agarose-chitosan-multiwalled carbon nanotubes for the preconcentration of selected nonsteroidal anti-inflammatory drugs in aqueous samples before determination by high performance liquid

[Effect of 3-oxypyridine and succinic acid derivatives on endometrial leucocyte infiltration and lipid peroxidation in recrudescence of inflammatory diseases of the uterus and its appendages].

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The effect of domestic 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin and mexidol) included in the complex treatment of recrudescence of inflammatory diseases of the uterus and its appendages, as manifested in endometrial leucocyte infiltration (ELI) compared to lipid peroxidation

[Research of anti-inflammatory activity of the thiosemicarbaziden-morpholinilacetic acid].

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Studying of synthesis and anti-inflammatory activity of a number of new derivatives of N-acylsubstituted of thiosemicarbazide and product of their heterocyclization (thiadiazole). In work the following reagents are used: hydrazide of N-morfolinilacetic acids, allil-, benzoil-, 4-brom-benzoil

Suitability of macrophage inflammatory protein-1beta production by THP-1 cells in differentiating skin sensitizers from irritant chemicals.

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BACKGROUND Worldwide restrictions in animal use for research have driven efforts to develop alternative methods. OBJECTIVE The study aimed to test the efficacy of the macrophage inflammatory protein-1beta (MIP-1beta) assay for testing chemicals' skin-sensitizing capacity. METHODS The assay was

Nrf2-mediated mucoprotective and anti-inflammatory actions of Artemisia extracts led to attenuate stress related mucosal damages.

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The aim of this study was to compare biological actions between isopropanol and ethanol extracts of Artemisia including antioxidant, anti-inflammatory, and cytoprotective actions. Antioxidant activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and confocal microscopy on

Isolation and tandem mass fragmentations of an anti-inflammatory compound from Aralia elata.

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One-step isolation of a saponin from Aralia elata was undertaken using high-speed countercurrent chromatography coupled with evaporative light scattering detection. A triterpenoid saponin, elatoside F, was purified with 96.8% purity using a two-phase-system comprising

Pharmacokinetics of celecoxib in the presence and absence of interferon-induced acute inflammation in the rat: application of a novel HPLC assay.

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OBJECTIVE Celecoxib (CEL) is a relatively new cyclooxygenase-2 specific inhibitor nonsteroidal anti-inflammatory drug with low incidents of the toxic side effects. We developed and validated an HPLC assay for CEL and delineated pharmacokinetics of the drug in the rat in the presence and absence of

High-performance liquid chromatography systems for the analysis of analgesic and non-steroidal anti-inflammatory drugs in forensic toxicology.

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High-performance liquid chromatography retention data are presented for over 40 analgesic drugs on an ODS-silica packing material to assist in the identification of these compounds. Three isocratic eluents prepared from isopropanol, formic acid and an aqueous phosphate buffer have been used. One

Electrochemical sensor system for breath analysis of aldehydes, CO and NO.

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Bulky and hyphenated laboratory-based analytical instrumentation such as gas chromatography/mass spectrometry is still required to trace breath biomarkers in the low ppbV level. Innovative sensor-based technologies could provide on-site and point-of-care (POC) detection of volatile biomarkers such

A straightforward LC-MS/MS analysis to study serum profile of short and medium chain fatty acids

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Short and medium fatty acids derived from either dietary sources, gut microbiota, and liver production might play a role in the modulation of metabolism and inflammation. The outcome of different autoimmune or inflammatory diseases could be related to microbiota composition and consequently fatty

Simultaneous determination of ZLR-8 and its active metabolite diclofenac in dog plasma by high-performance liquid chromatography.

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ZLR-8 is a nitric oxide releasing derivative of diclofenac for the treatment of inflammation. In this paper, a sensitive and reliable high-performance liquid chromatography method for simultaneous determination of ZLR-8 and its active metabolite diclofenac in the plasma of beagle dogs has been

Carrier free rapamycin loaded drug eluting stent: in vitro and in vivo evaluation.

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In the search for improving the performance of drug eluting stent (DES) various developments are in progress worldwide including use of carrier free DES, use of biodegradable polymers, biodegradable stents etc. In this work, carrier free-rapamycin (RM) coated DES has been prepared, and evaluated by

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