This invention relates to methods and compositions of tripeptides and dipeptides having anti-inflammatory activities that can be used for the treatment of allergic and inflammatory reactions. A peptide of the formula:orwherein X is selected from the group consisting of H and acetyl; R.sub. 1 is selected from the group consisting of D or L-phenylalanine; tyrosine; tryptophan; phenylglycine; Nor-methylphenylalanine; cyclohexylalanine; and norleucine; R.sub.2 is selected from the group consisting of D or L-glutamate; and aspartate; and in the case of peptide (II), R.sub.3 is selected from the group consisting of glycine; D or L-alanine; beta-alanine; valine; leucine; isoleucine; sarcosine; and gamma-aminobutyric acid or another aliphatic amino acid; and Y is selected from the group consisting of OH and NH.sub.2, but excluding the dipeptides H-L-Phe-L-Glu-OH, H-L-Trp-L-Glu-OH, H-D-Phe-D-Glu-OH and H-D-Trp-D-Glu-OH.

Salpep Biotechnology, Inc.

Treating allergic reactions and inflammatory responses with tri-and dipeptides

The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-diflu- orophenyl}ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-diflu- orophenyl}ethyl)-L-alanine.

Macrophage Pharma Limited

Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-YL]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof

Chroma Therapeutics Ltd.

Chroma Therapeutics Ltd

Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof

Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt,hydrate or solvate thereof

l alanine

uždegimas

inflammation

l alanine/uždegimas

Treating allergic reactions and inflammatory responses with tri-and dipeptides

Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-YL]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof

Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof

Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt,hydrate or solvate thereof

Išsamiausia vaistinių žolelių duomenų bazė, paremta mokslu