Day 1: Patients receive two doses 400 mg of Hydrochloroquine in 12 hours interval and 500 mg of Azithromycin once in 24 hours (with the first dose of hydrochloroquine)
Days 2-5: Patients receive two doses 200 mg of Hydrochloroquine in 12 hours interval 250 mg of Azithromycin once in 24 hours (with the first daily dose of hydrochloroquine)

Day 1: Patients receive two doses 400 mg of Hydrochloroquine in 12 hours interval and placebo once in 24 hours (with the first dose of hydrochloroquine)
Days 2-5: Patients receive two doses 200 mg of Hydrochloroquine in 12 hours interval and placebo once in 24 hours (with the first dose of hydrochloroquine)

• Day 1-5: Patients receive two doses of placebo in 12 hours interval and 1 extra dose of placebo once in 24 hours

COVID-19

Respiratory Failure

orally or into nasogastric tube for 5 days

Azithromycin

Hydroxychloroquine

Placebo

František Duška

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care Due to Coronavirus Disease 2019 (COVID-19)- Randomised Controlled Trial

Composite percentage of patients alive and not on end-of-life pathway who are free of mechanical ventilation at day 14.

Composite percentage of patients alive and not on end-of-life pathway who are free of mechanical ventilation at day 14 in the subgroup of patients without the need of mechanical ventilation at baseline.

Proportion of patients who died by day 28

Proportion of patients who died by day 90

Deidentified record-level data will be shared in a public database

Frantisek Duska, MD, PhD

Masaryk Hospital Usti nad Labem

University Hospital Pilsen

The Faculty Hospital Na Bulovce

St. Anne's University Hospital Brno, Czech Republic

University Hospital, Motol

General University Hospital, Prague

University Hospital Olomouc

Prospective, multi-centre, randomised, pragmatic, double blind trial

Visually unrecognisable IP or placebo will be prepared by dedicated unblinded study pharmacist and handed over to care provider immediately before administration

In this arm, subjects consumed a beverage

In this arm, subjects consumed a beverage with identical macronutrients

Inflammation

Milk fat globule membrane

Effect of Milk Fat Globule Membrane (MFGM) on Gut Barrier Protection in Runners

In this outcome, the barrier properties of the gut are assessed indirectly. Subjects consume a mixture of lactulose and mannitol. Mannitol is a monosaccharide and is passively absorbed from the gut and eliminated via the urine. Lactulose, on the other hand, is an indigestible disaccharide. If it appears in the urine, it is thought to pass into the body through loose tight junctions between the mouth and large intestine. If it reaches the large intestine, lactulose will be fermented by the microbiome.
Subjects consume the sugar mixture and urine is collected for 6 hours. In this study, gut permeability was measured at baseline, and after after the running tests.

Higher core temperatures are associated with increased gut permeability. Two of our primary measures were gut permeability assessments by the differential sugar test and plasma LPS. The increase in core temperature was included to give context to those measures. Prior to the exercise test, subjects consumed a thermometer pill and core temperature was monitored with a recording device.

Plasma lactate was measured as an index of exercise intensity. It was measured before the exercise challenge, and immediately after. It was also measured at 1 hour and 4 hours post exercise.

To determine the systemic inflammatory response, plasma cytokines were measured before the exercise test and at 1h and 5h later. Plasma cytokines were measured with a multiplexed ELISA kit.

Higher levels of plasma endotoxin (aka LPS) are thought to occur due to a leaky gut

Creatine kinase was measured as an index of muscle stress. It was measured before the exercise challenge, and immediately after. It was also measured at 1 hour and 4 hours post exercise.

Robert Ward

Associate Professor

Utah State University

Dairy Research Institute

Solution for infusion administrated via nasogastric tube

30 mg melatonin administrated via nasogastric tube in the Intensive Care Unit when included in the study and 30 mg melatonin 60 minutes before transfer to the operating room.

Evidence of Liver Transplantation

Melatonin 2 mg prolonged-release tablet, administration via nasogastric tube.

Melatonin

Hospital Clínico Universitario Lozano Blesa

Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.

Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant: a Prospective, Randomised Double-blind Study.

Aspartate transaminase (AST) levels will be measured.

Alanine transaminase (ALT) levels will be measured.

No primary function and primary graft dysfunction

Donor and recipient serological parameters

Morphological and functional quality of the liver graft evaluated by histological parameters of ischemia-reperfusion and tissue biochemical markers

Aragon Institute of Health Sciences

Fondo de Investigacion Sanitaria

Pulmonary Tuberculosis

Zinc miconutrient supplements have been prepared by Cadila pharmaceutical Ltd., India, in the form of capsules.Each micronutrient capsule contains 50mg zinc (as zinc sulphate) in a lactose matrix.In this clinical trial one tablet of zinc as oral supplement will be given everyday during the entire course in line with the directly observed treatment, short-course (DOTS) strategy recommended by the World Health Organization.

Zinc supplement

Placebo have been prepared by Cadila pharmaceutical Ltd., India, in the form of capsules.The placebo consisted of lactose alone. Supplement and placebo capsules were indistinguishable in appearance both externally and internally.

All India Institute of Medcial Sciences-

Efficacy of Oral Zinc Administration as an Adjunct Therapy in New Pulmonary Tuberculosis (Category I) Patients

Efficacy of Oral Zinc Administration as an Adjunct Therapy in Category I Pulmonary Tuberculosis Along With Assessment of Immunological Parameters (Double-blind, Randomized, Placebo-Controlled, Multicenter Clinical Trial

lactose/hypoxia

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial

Effect of Milk Fat Globule Membrane (MFGM) on Gut Barrier Protection in Runners

Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.

Efficacy of Oral Zinc Administration as an Adjunct Therapy in New Pulmonary Tuberculosis (Category I) Patients

Išsamiausia vaistinių žolelių duomenų bazė, paremta mokslu