lysophosphatidylcholine/seizures

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[Metabolism of neuronal and neuroglial phospholipids in seizures].

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Metabolism of individual phospholipids was studied in neurones and neuroglia under conditions of convulsions caused by picrotoxin administration. Metabolic activity of all the phospholipids studied was increased in neuronal membranes under extreme conditions of convulsive attacks. The rate of

Effect of picrotoxin-induced seizures on lipid composition of cortical tissue homogenate and its nuclear fraction in rats.

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The content of lipids in rat cortical tissue homogenate and fraction of neuronal nuclei was determined under normal conditions and after picrotoxin-induced seizures. Changes in lipid composition of homogenate and nuclear fraction differed considerably. In homogenate, the content of sphingomyelin,

Influence of seizures on lipids of homogenate and neuronal and glial nuclei of rat neocortex.

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Lipid composition of homogenate and neuronal and glial nuclei of the brain cortex of Wistar rats was studied under normal conditions and after seizures induced by injection of picrotoxin. Seizures increased contents of lysophosphatidylcholine, sphingomyelin, and total phospholipids in the

The biochemical and behavioral effects of phospholipase A2 and morphine microinjections in the periaqueductal gray of the rat.

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In order to characterize the in vivo action of phospholipase A2 (PLA2) on opiate receptors and opiate-induced behaviors, the effects of injections of PLA2 into the periaqueductal gray region (PAG) of the rat were assessed on free fatty acid (FFA) release, opiate-binding levels, and morphine-induced

Secretory phospholipase A2 and phospholipids in neural membranes in an experimental epilepsy model.

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OBJECTIVE Previous studies have revealed an increase in several forms of phospholipase A2 activity associated with cell injury, but the secretory form of phospholipase A2 has not previously been studied in neurological disorders. We investigated the influence of seizures on secretory phospholipase

[State of biological membranes in rats tissues with different audiogenic susceptibility].

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The decrease of sphingomyelin in synaptosomes of brain hepatocytes, erythrocytes and the increase of lysophosphatidylcholine in hepatocytes and erythrocytes were found in rats with high seizure susceptibility. Activities of acetylcholinesterase and Mg(2+)- and Ca(2+)-ATPase were not changed.

[Qualitative and quantitative changes in phospholipid spectra of the brain of rats with corazol-induced epilepsy].

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The enhancement of the sum of phospholipids in seizure period was observed during initially generalized corazol seizure in white rats' cerebral cortex. This sum fell in an hour after epileptic fit. It is noted that the maintenance of lysophosphatidylcholines and phosphatidylserines enhanced during

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