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Puslapis 1 nuo 459 rezultatus
Imaging of Melanin Disruption in Age-Related Macular Degeneration Using Multispectral Imaging.
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OBJECTIVE
To investigate whether multispectral imaging (MSI) is able to obtain a noninvasive view of melanin disruption associated with age-related macular degeneration (AMD), which could support early diagnosis and potential treatment strategies.
METHODS
A single retinal center, retrospective,
Selectivity of melaninized nigra-striatal dopamine neurons to degeneration in Parkinson's disease may depend on iron-melanin interaction.
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The recent studies on the chemical pathology of Parkinson's disease show selective increases of iron and lipid peroxidation and decreased glutathione (GSH) oxidizing capacity in the substantia nigra (SN). These changes are indicative of oxidative stress, possibly due to the accumulation of iron in
The distribution of melanin in the developing optic cup and stalk and its relation to cellular degeneration.
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The early distribution of melanin in the developing optic cup and stalk and its relationship to cellular degeneration have been studied during intrauterine development in hamsters, mice, ferrets, and humans. The extensive degenerative changes that occur in the region of the optic fissure do not
Fungal melanins that deteriorate paper cultural heritage: An overview
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Paper-based works of art and documents of cultural importance kept in museums and libraries can show notorious signs of deterioration, including foxing stains, caused by fungal colonization. Some of the main chromophore agents of fungal origin that deteriorate paper and therefore affect paper
Cationic poly-l-lysine-encapsulated melanin nanoparticles as efficient photoacoustic agents targeting to glycosaminoglycans for the early diagnosis of articular cartilage degeneration in osteoarthritis.
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Cartilage degeneration is the hallmark of osteoarthritis (OA) and its early diagnosis is essential for effective cartilage repair. However, until now, there was still a lack of imaging modalities that can accurately detect and evaluate cartilage degeneration in its early stage. Herein, we introduce
Melanin aggregation and polymerization: possible implications in age-related macular degeneration.
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The state of aggregation of the polymer melanin may determine its propensity to act either as an antioxidant or as a pro-oxidant. Age-related alterations in its state of aggregation are suggested to alter the degree of polymerization so as to confer increased pro-oxidant propensity to the melanin
[Results reached in the treatment of primary tapeto-retinal degeneration and of other diseases of the macular region by hyophyseal melanin extract "senac"].
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Characterization of Retinal Pigment Epithelial Melanin and Degraded Synthetic Melanin Using Mass Spectrometry and In Vitro Biochemical Diagnostics.
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With increasing age, there is an observable loss of melanin in retinal pigment epithelial (RPE) cells. It is possible that degradation of the pigment contributes to the pathogenesis of retinal disease, as the cellular antioxidant material is depleted. Functionally, intact melanin maintains
Quantification of melanin in hepatic and cardiac lipofuscin.
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Melanin pigment in liver and heart tissue, obtained at autopsy from patients, was isolated and quantified. The quantity of melanin extracted was directly proportional to lipofuscin granule counts. Infrared and electron spin resonance spectographs of the isolated pigments from liver and heart showed
Melanin granule in skin window macrophages.
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Pigment granules have been studied in macrophages of skin window preparations. These granules usually appeared blue with Romanowsky stains, and stained positively for melanin but negatively for iron. There were significantly more pigment granules per macrophage in sun-tanned individuals and in
Monte Carlo investigation on quantifying the retinal pigment epithelium melanin concentration by photoacoustic ophthalmoscopy.
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The retinal pigment epithelium (RPE) melanin plays an important role in maintaining normal visual functions. A decrease in the RPE melanin concentration with aging is believed to be associated with several blinding diseases, including age-related macular degeneration. Quantifying the RPE melanin
Retinal degeneration in celestial goldfish. Developmental study.
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The celestial goldfish were systematically reared from fertilization for life, revealing developmental processes of retinal degeneration. The eyes began to protrude laterally at the age of 90 days, rotated antero-dorsally at 120 days, and thus the 'celestial eye' was completed. The retina developed
Melanosome abnormalities of ocular pigmented epithelial cells in beagle dogs with hereditary tapetal degeneration.
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Eyes of laboratory beagle dogs with an inherited tapetal degeneration were abnormally lightly pigmented. The development of pigmentation was followed morphologically from 7 days postnatal to 9 years of age. At all postnatal ages the iris pigmented epithelia contained no normal melanosomes, only
Retinal pigment epithelial correlates of avian retinal degeneration: electron microscopic analysis.
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The delayed amelanotic (DAM) strain of domestic chicken is characterized by an early, developmental onset of choroidal inflammation and destruction of both feather and choroidal melanocytes. Secondarily, retinal pigment epithelial (RPE) cells in the peripapillary region develop abnormalities, and a
Retinal ultrastructural findings in cone degeneration.
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We studied an eye from a 73-year-old man with a sporadic type of retinal cone degeneration and choroidal melanoma. Histologic and ultrastructural studies of the nasal retina unaffected by the choroidal melanoma showed alterations at the outer retina predominantly involving the photoreceptors and
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