LCP-tacrolimus administered daily to target a goal trough level of 10-14 ng/mL x 7 months (with Mycophenolate mofetil and prednisone).
Additional standard immunosuppression with either mycophenolate mofetil (500-1500mg twice daily) OR Azathioprine (up to 2mg/kg daily) AND Prednisone (5-10mg daily) will be administered.

IR-tacrolimus administered twice daily to target a goal trough level of 10-14 ng/mL x 7 months (with Mycophenolate mofetil and prednisone). This is currently the standard of care at Vanderbilt University Medical Center and most other lung transplant centers (ISHLT Registry 2019).
Additional standard immunosuppression with either mycophenolate mofetil (500-1500mg twice daily) OR Azathioprine (up to 2mg/kg daily) AND Prednisone (5-10mg daily) will be administered.

Lung Transplant; Complications

Immunosuppression regimen with Tacrolimus Extended Release as the backbone.

Tacrolimus Extended Release Oral Tablet [Envarsus]

Standard Immunosuppression regimen with Intermediate-Release Tacrolimus.

Tacrolimus

Standard immunosuppression of the anti-proliferative class.

Mycophenolate Mofetil Hydrochloride

Standard immunosuppression (corticosteroid class).

Prednisone

Azathioprine

Vanderbilt University Medical Center

Early Use of Long-acting Tacrolimus in Lung Transplant Recipients

A Prospective, Randomized, Controlled Pilot Study of Early-Use Long Acting Tacrolimus (Envarsus XR) in Lung Transplant Recipients

Composite of mortality, allograft failure, potential drug induced liver injury, supra-therapeutic trough levels (>20 ng/mL), sub-therapeutic trough levels (<5 ng/mL), seizures, encephalopathy, thrombotic microangiopathy and serious hyperkalemia associated with use of LCP-tacrolimus, compared to matched historical controls administered IR-tacrolimus.

Median change in eGFR from study start to 9 months post-transplantation with patients administered LCP-tacrolimus compared to IR-tacrolimus.

Quality of life related to headache frequency and severity using the Headache Impact Tool (HIT-6).

Quality of life related to tremor as measured by the QUEST tool.

Incidence of acute cellular rejection (>= A1) or lymphocytic bronchiolitis (>= B1R)

Incidence of de novo donor-specific anti-HLA antibodies (MFI > 1500) within the first 9 months post-transplant.

Anil Trindade

Assistant Professor of Medicine

Veloxis Pharmaceuticals

Prospective, randomized, controlled pilot study.

Any SLE patients between 18 and 40 years old.

Effect of Gender on Clinical Presentation of SLE ِAt Assiut University Hospitals

Using percentages, we will track the number of patients that develop certain clinical conditions (such as arthritis, malar rash, .... ), complications (such as nephritis), and mortality rates. These numbers and percentages will be used to compare males with females (incidence rates for each event will be calculated).

Ahmed Safwat ِِِAbd elhamid eltaih

Principal Investigator

Assiut University

Hospitalized Cases of Angioneurotic Oedema

Pneumonia

Gastroenteritis

Failure to Thrive

Seizures

Acute Interstitial Nephritis and Thrombocytopenia

D9612N00016 Children Study report synopsis Final redacted

nephritis/seizures

Early Use of Long-acting Tacrolimus in Lung Transplant Recipients

Effect of Gender on Clinical Presentation of SLE ِAt Assiut University Hospitals

Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists

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