Preeclampsia

rosuvastatin

Effect of Rosuvastatin on the Clinical Features of Preeclampsia

Effect of Rosuvastatin on Sever Preeclampsia Induced Inflammatory Response

The primary outcome will be the effect of rosuvastatin on the resolution of biochemical features associated with severe PE (↑CRP and IL6).

Sara Mansour

assistant lecturer on anasthesia and icu department

Assiut University

. They will be randomly allocated into two equal groups of 40 parturient each: Group 1: 40 preeclamptic parturient receive 20 mg rosuvastatin orally once daily.
Group 2: 40 preeclamptic parturient receive 40 mg rosuvastatin orally once daily

computer generated randomization will be conducted in a Women's Health Hospital, Assuit University. Neither the doctor "investigator" nor the participant "parturient" will be aware of the group allocation or the drug used. The study drugs will be prepared by one of the supervisor anesthesia (not included in the procedure, observation or in data collection)

Pregabalin 150mg oral tablets before one hour before undergoing unilateral total knee arthroplasty

tapentadol 100mg oral tablets before one hour before undergoing unilateral total knee arthroplasty

Osteoarthritis, Knee

This arm will receive drugs one hour before undergoing unilateral total knee arthroplasty. Interventions tapentadol 100mg oral tablets.

Tapentadol 100 MG Oral Tablet

This arm will receive drugs one hour before undergoing unilateral total knee arthroplasty. Interventions pregabalin 150mg oral tablets.

Pregabalin 150mg

All India Institute of Medical Sciences

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Unilateral Total Knee Arthroplasty- A Randomised, Double Blind, Active Control, Clinical Trial

Visual analogue scale (VAS) from 0 to 100 mm score at 0,6,12,24 hrs. post operatively in both the groups.

Scoring on TOTPAR scale at 0,6,12,24 hrs. post operatively in both the groups

Mean difference in total analgesic consumption in both the groups post operatively

Frequency of nausea and vomiting in both the groups.

On a scale (None, Mild, Moderate, Severe) in both the groups.

Reduction of VAS to 3 at the end of 6 hours and 12 hours without nausea and vomiting

Dr Debasish Hota

PROFESSOR AND HEAD OF THE DEPARTMENT PHARMACOLOGY

All India Institute of Medical Sciences, Bhubaneswar

This study will be participant and investigator blinded. Allocation concealment will be done by sequentially numbered sealed drug pouches.

Patients will take esomeprazole single dose of 40 mg orally once a day

Patients will take an inert tablet similar in appearance, color and consistency

Esomeprazole 40 mg Oral Tablet

Placebo Oral Tablet

Assiut Faculty of Medicine

Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial)

Use of Esomeprazole in Treatment of Early Onset Preeclampsia:a Double Blind Randomized, Placebo-controlled Trial

Ahmed Mohamed Abbas

Principal investigator

placebo (2 ml normal saline) administered intravenously at dural closure during craniotomy

parecoxib 40 mg in 2 ml normal saline administered intravenously at dural closure during craniotomy

oxygenase/seizures

Effect of Rosuvastatin on the Clinical Features of Preeclampsia

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery

Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial)

Effect of Parecoxib on Post-craniotomy Pain

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