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Golimumab in Juvenile Idiopathic Arthritis-associated Uveitis Failing Adalimumab

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Background: Uveitis is a potentially blinding complication of juvenile idiopathic arthritis (JIA). Treatment remains a substantial challenge, even though the use of tumor necrosis factor (TNF)-α-antagonists has improved visual outcomes substantially. Among these agents, adalimumab has been recently

RCT of SPG Blocks for Post-dural Headache

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The postdural puncture headache (PDPH) is a well-documented complication of dural puncture. Depending on a number of factors, the overall incidence of PDPH following unintended dural puncture with an epidural placement needle is typically around 50%, but can be as high as 70% for certain

Comparison of 1,550 and 755 Laser in a Split-face Trial

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This is a Clinical Trial comparing the 1,550-nanometer fractionated photothermolysis system laser to the 755 nanometer picosecond laser using a split-face (Right-Left) comparison. Both of these lasers are currently FDA approved for acne scarring. Approximately 18 subjects, men and women with

Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients

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Uveitis represents a heterogeneous group of diseases that results from ocular inflammatory reaction involving ocular tissue and vasculature. The inflammation usually causes pain, redness, photophobia and blurred vision. H.P Acthar Gel stimulate the adrenal cortex to secrete cortisol. Additionally

A Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Subcutaneous Histamine Dihydrochloride for Migraine Prophylaxis

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BACKGROUND Migraine headaches affect more than 28 million persons in the United States (Foundation). Approximately 25% of women and 9% of men experience migraine headaches (Rasmussen BK, 1991) (Lipton RB, 1993) (Ramadan NM, 2002). Individuals with migraine headaches lose an average of 4 to 6 working

Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache

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A urine pregnancy test will be performed on women of child bearing age. After informed consent is obtained, each patient will be placed in a dark private room and asked to grade nausea, pain, and sedation on a 10 cm visual analog scale, using the left end as the zero point for complaints and

Infliximab to Treat Non-Infectious Scleritis

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We propose to investigate the possible efficacy of multiple infliximab infusions to control the inflammation in participants presenting with active scleritis. This will be performed using an open-label pilot study. Subjects will receive 5mg/kg intravenous infusions of infliximab at 0, 2, 6 and 10

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