pyrrolizidine/vėžys

Nuoroda įrašoma į mainų sritį

Pasirinkite rūšiavimo tipą

Puslapis 1 nuo 71 rezultatus

Induction of endogenous avian tumor virus gene expression by pyrrolizidine alkaloids.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

The pyrrolizidine alkaloids (PA) are toxic compounds which occur naturally in plant species throughout the world. They have been implicated as both carcinogenic and mutagenic agents. An active metabolite of the alkaloids, the pyrrole, which is a strong alkylating agent, is thought to be the

Estimated intakes of pyrrolizidine alkaloids by humans. A comparison with dose rates causing tumors in rats.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Pyrrolizidine alkaloid poisoning in humans is associated with the consumption of plants containing the alkaloids, either as contaminants of grains or as infusions for medicinal purposes. The alkaloids are carcinogenic in rats but have not been associated, so far, with tumors in humans. For the known

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Large outbreaks of acute food-related poisoning, characterized by hepatic sinusoidal obstruction syndrome, hemorrhagic necrosis, and rapid liver failure, occur on a regular basis in some countries. They are caused by 1,2-dehydropyrrolizidine alkaloids contaminating locally grown grain. Similar acute

Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Induction of hepatic tumors in rats by senkirkine and symphytine.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

The carcinogenicity of the pyrrolizidine alkaloids senkirkine and symphytine was studied in male inbred ACI rats. Animals were divided into 3 groups: Group I received ip injections of freshly prepared senkirkine at a dose of 10% of the median lethal dose (LD50) twice weekly for 4 weeks and then once

Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Humans and animals can be exposed to carcinogenic pyrrolizidine alkaloids (PAs) through consumption of plants commonly found in many parts of the world. Although the liver is the primary target organ for carcinogenic PAs, they have also induced lung tumors in rodents. Hepatic cytochrome P450

Pyrrolizidine alkaloids from the seeds of Scleropyrum wallichianum.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Two new pyrrolizidine alkaloids, sclerwalins A and B (1 and 2), and one known 9-O-E-hydroxysenecioylretronecine (3) were first isolated from the seeds of Scleropyrum wallichianum. Their chemical structures were elucidated by extensive 1 D NMR and 2 D NMR (HSQC, HMBC,

CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

The carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata, was studied in inbred ACI rats. Twelve animals in the experimental group received a 0.005% solution of clivorine in drinking water for 340 days and survived beyond 440 days after the beginning of the

Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites japonicus Maxim.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

The carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from young flower stalk of Petasites japonicus, was studied in ACI rats. All rats that had received a 0.05% solution of petasitenine in drinking water died or were killed in moribund condition 72 days after the start of

Effect of prednisone on transforming growth factor-β1, connective tissue growth factor, nuclear factor-κBp65 and tumor necrosis factor-α expression in a murine model of hepatic sinusoidal obstruction syndrome induced by Gynura segetum.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

OBJECTIVE One major cause of hepatic sinusoidal obstruction syndrome (HSOS) is the consumption of products containing pyrrolizidine alkaloids (PA). As the use of herbal preparations has increased in China, so has the number of reports of HSOS induced by ingesting PA-containing herbs. The aim of the

Transplantation of normal hepatocytes modulates the development of chronic liver lesions induced by a pyrrolizidine alkaloid, lasiocarpine.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Lasiocarpine (LC), a pyrrolizidine alkaloid, is able to induce a series of chronic and progressive lesions in rat liver, including a long-lasting block in the cell cycle, the appearance of enlarged hepatocytes (megalocytosis), fibrosis, cirrhosis and malignant neoplasma. In this study the effect of

Hepatotoxic Pyrrolizidine Alkaloids Induce DNA Damage Response in Rat Liver in a 28-day Feeding Study

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans and animals, comprising liver pain, hepatomegaly and the development of ascites due to occlusion of the hepatic sinusoids

Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids

Identification of markers of cancer in urban sewage through the use of a suspect screening approach.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

The administration of anticancer drugs during chemotherapy treatments has increased considerably in recent years, and based on the growing incidence of cancer worldwide there is a foreseen increase in their use over the coming years. Many anticancer drugs are not removed by conventional wastewater

Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues.

Straipsnius versti gali tik registruoti vartotojai

Prisijungti Registracija

Repeated topical doses of dehydromonocrotaline, a putative primary toxic metabolite of the pyrrolizidine alkaloid monocrotaline, followed by repeated treatments with croton oil, produced malignant tumours of the skin in LACA mice. A chemically similar alkylating agent,

Ankstesnis
1
2
3
4
5
Kitas

Prisijunkite prie mūsų
„Facebook“ puslapio

Herbal & Natural Medicine

Išsamiausia vaistinių žolelių duomenų bazė, paremta mokslu

Dirba 55 kalbomis
Žolelių gydymas, paremtas mokslu
Vaistažolių atpažinimas pagal vaizdą
Interaktyvus GPS žemėlapis - pažymėkite vaistažoles vietoje (netrukus)
Skaitykite mokslines publikacijas, susijusias su jūsų paieška
Ieškokite vaistinių žolelių pagal jų poveikį
Susitvarkykite savo interesus ir sekite naujienas, klinikinius tyrimus ir patentus

Įveskite simptomą ar ligą ir perskaitykite apie žoleles, kurios gali padėti, įveskite žolę ir pamatykite ligas bei simptomus, nuo kurių ji naudojama.
* Visa informacija pagrįsta paskelbtais moksliniais tyrimais