rubidium/seizures

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Onset of audiogenic seizures in rodents after intake of near-toxic doses of rubidium chloride.

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Rats and mice that were not genetically or otherwise predisposed toward audiogenic seizures were rendered susceptible to auditory stimuli by chronic treatment with large doses of rubidium chloride (RbCl). Animals given drinking water, 0.03 N with respect to RbCl, for four weeks responded with

Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium.

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The neuro-protective effects of rubidium and lithium as alkali metals have been reported for different central nervous system dysfunctions including mania and depression. The aim of this study was evaluating as well as comparing the effects of rubidium chloride (RbCl) and lithium chloride (LiCl) on

A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.

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The neuronal K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration required for the hyperpolarizing actions of inhibitory neurotransmitters gamma-aminobutyric acid and glycine in the central nervous system. This study shows that the mammalian KCC2 gene (alias Slc12a5)

Magnetoencephalography of epilepsy with a microfabricated atomic magnetrode.

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Magnetoencephalography has long held the promise of providing a noninvasive tool for localizing epileptic seizures in humans because of its high spatial resolution compared with the scalp EEG. Yet, this promise has been elusive, not because of a lack of sensitivity or spatial resolution but because

Metrazol thresholds in inbred and non-inbred audiosensitive mice.

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Mice of the O'Grady strain which were inbred for susceptibility to audiogenic seizures were found to be more sensitive to pentamethylenetetrazol (Metrazol) convulsions than mice of the parent Swiss-Webster strain from which they were originally derived. A dose of 35 mg/kg Metrazol was required to

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