sclerosis/phosphatase

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Straipsniai Klinikiniai tyrimai Patentai

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Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction

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The leading cause of death in the world is due to cardiovascular events, which originate from coronary artery stenosis therefore it affects myocardial blood flow and finally may cause infarction. ST-Segment elevation is an indicator of infarction (STEMI) in electrocardiography (ECG) besides cardiac

Vulvodynia: Identification of Potential Relevant Biomarkers

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Sphingosine-1-phosphate (S1P) is a potent anti-apoptotic sphingolipid with potent pro-inflammatory actions which are driven in most part by activation of the S1P receptor subtype S1PR158. Biologically active S1P is generated by the phosphorylation of sphingosine, catalyzed by two sphingosine kinases

Fecal Microbiota Transplantation for the Treatment of Primary Sclerosing Cholangitis.

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Background and Significance: Primary sclerosing cholangitis (PSC) is a progressive, chronic cholestatic liver disease characterized by inflammatory and fibrotic destruction of the intrahepatic and/or extrahepatic bile ducts. PSC will progress to biliary cirrhosis, portal hypertension and liver

Whole Gut Microbiome Sequencing in Patients With Anorexia Nervosa

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BACKGROUND Anorexia nervosa (AN) is a complex disorder characterized by disturbed body image, ego-syntonic neglect, ambivalence, self-starvation, loss of body weight, obsessive thoughts of food, ritualistic patterns of food intake, elevated physical activity, depression, anxiety and emotional

Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis

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Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic disease associated with the development of cirrhosis and liver failure that may justify liver transplantation. Ursodeoxycholic acid (UDCA) is currently the only drug approved specifically for the treatment of PBC. However, one out

Role of Nox2 in CNI-induced Renal Fibrosis

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Calcineurin Inhibitors (CNIs) and Renal Fibrosis. CNIs including CsA and tacrolimus are the cornerstone of maintenance immunosuppression in solid organ transplantation. These drugs are so effective that newer generation CNIs such as Voclosporin (Isotechnika Pharma, Inc, Edmonton, Alberta) are in

Graz Osteoprotegerin as a Risk Factor (GORF) Study

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Steroids and Azathioprine in Advanced IgAN

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It is know well established that IgAN outcome is often unfavourable, with end-stage renal disease (ESRD) occurring in 5-25% of cases within ten years and in 25-50% of cases within 20 years. The degree of impairment in renal function at presentation is certainly an important predictor of this poor

The Effects of Interferon Beta Combined With Vitamin D on Relapsing Remitting Multiple Sclerosis Patients

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Detailed Description of Study Evaluations Adherence to treatment evaluation: Patients will be asked to bring the empty packages of the IFN beta and Vitamin D that were used during the study. Flu like symptoms and Injection site reactions evaluation: Data regarding FLS and ISRs will be collected by

Vascular Calcification's Risk Factors in Haemodialysis Patients

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Cardiovascular diseases (CVD) are the main causes of death and hospitalization in patients affected by ESRD . The risk of death from CVD is already detectable in the early steps of chronic renal failure and it is from 20 to 30 times higher than in the general population. In ESRD patients the

A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis

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Systemic sclerosis is a rare, progressive disease that leads to hardening and tightening of the skin and connective tissues. It usually begins with a few dry patches of skin on the hands or face that begin getting thicker and harder. These patches then spread to other areas of the skin. In some

Comparison of Bone Effects With Copaxone and Interferon in Multiple Sclerosis

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There will be 60 female patients with MS at University of Kansas Medical Center (KUMC). They will be split into two groups: a Copaxone group and an Interferon (Avonex, Rebif, or Betaseron) group. Each group will be composed of 30 women matched for menopausal status. Each subject will be given a

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