thrombocytopenia/hypoxia

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Hypoxia as a predisposing factor for the development of early onset neonatal thrombocytopenia.

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BACKGROUND Thrombocytopenia in hypoxic neonates admitted in NICU is a morbid condition encountered very commonly. Early-onset thrombocytopenia (<72 h) is most commonly associated with fetomaternal conditions complicated by placental insufficiency and/or fetal hypoxia. Chronic intrauterine hypoxia is

Transitory thrombocytopenia in newborn mice after intrauterine hypoxia.

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Pregnant mice were exposed to hypobaric hypoxia (0.7 atmospheres) continuously during days 13 to 20 of pregnancy. In the newborn offspring, the body weights were decreased, and liver weight/body weight ratios were increased compared to nonhypoxic control animals (P < 0.001). After intrauterine

[Cardiac angiosarcoma with gastrointestinal bleeding, hypoxemia, thrombocytopenia and microangiopathic hemolytic anemia].

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This report describes cardiac angiosarcoma in a 62-year-old man. The patient presented with metastatic pulmonary and extradural spinal cord tumors of unknown origin. During the course, he developed hypoxemia, gastrointestinal bleeding, thrombocytopenia, and microangiopathic hemolytic anemia.

Hypoxia-induced thrombocytopenia in mice.

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In mice hypoxic hypoxia (0.5 atm.) results in a severe and persistent thrombocytopenia with a rapid decline in the platelet count between the fifth and ninth days of hypoxia, after which platelet counts level off at about half their normal value. The thrombocytopenia is not due to the associated

Downregulation of hypoxia-inducible factor-1α contributes to impaired megakaryopoiesis in immune thrombocytopenia.

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Impaired megakaryocyte maturation and exaggerated platelet destruction play a pivotal role in the pathogenesis of immune thrombocytopenia (ITP). Previous studies have shown that HIF-1α promotes the homing and engraftment of haematopoietic stem cells (HSCs), thereby stimulating HSC differentiation.

[Thrombocytopenia, hypoxia and fat embolism syndrome after severe injury].

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Erythroblastemia and thrombocytopenia in small for gestational age infants: relation to intrauterine hypoxia, infections and maternal smoking.

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Febrile disease in a Bulgarian emigrant with acute renal failure, thrombocytopenia, bilateral subconjunctival haemorrhage and hypoxemia.

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Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-1989. A 26-year-old woman with fever, diarrhea, leukopenia, thrombocytopenia, and hypoxemia.

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Thrombopoietin expression in normal and hypobaric hypoxia-induced thrombocytopenic rats.

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Thrombopoietin (TPO) is important as the physiologic regulator of platelet production. High-altitude hypoxia is a well-known cause of polycythemia and thrombocytopenia in animals. Fifty-two Wistar rats were housed for 0.5 to 21 days in a mechanical chamber in an environment equivalent to that found

Effects of hypoxia on the small acetylcholinesterase-positive megakaryocyte precursor in bone marrow of mice.

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The number of small acetylcholinesterase-positive (SAChE+) cells in the marrow of hypoxic mice was measured. Mice were exposed to 6-7% O2 levels by enclosure in cages covered with dimethyl-silicone rubber membranes for 1-14 days. The mice showed a linear increase in packed cell volumes with time in

Megakaryocytopoiesis in experimentally induced chronic normobaric hypoxia.

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It was recently proposed that prolonged hypoxia produces hypomegakaryocytic thrombocytopenia by reducing the pool of committed megakaryocyte progenitor cells at the expense of a greatly expanded erythroid progenitor pool. In order to test this hypothesis we have studied the relationship between

Thrombocytopenia in late preterm and term neonates after perinatal asphyxia.

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BACKGROUND A recent NHLBI conference concluded that platelet (PLT) transfusions of neonates must become more evidence based. One neonatal disorder for which transfusions are given is a poorly defined entity, the "thrombocytopenia of perinatal asphyxia." To expand the evidence base for this entity,

Severe Thrombocytopenia in an Immune Thrombocytopenic Parturient Non-responder to Medical Line of Treatment: Anaesthetic Management for Splenectomy Combined with Caesarean Section.

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We report anaesthesia management of a parturient with severe thrombocytopenia secondary to immune thrombocytopenic purpura (ITP). Her platelet count remained around 3 × 10(9)/l in spite of optimum medical therapy and hence was posted for splenectomy combined with caesarean section. Anaesthesia

A Case Report of an Elderly Woman With Thrombocytopenia and Bilateral Lung Infiltrates: A Rare Association Between Diffuse Alveolar Hemorrhage and Idiopathic Thrombocytopenic Purpura.

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Etiologies for diffuse alveolar hemorrhage are wide and range from infectious to vasculitis and malignant processes. Idiopathic thrombocytopenic purpura is an autoimmune disorder characterized by persistent thrombocytopenia, with a relatively indolent course in young patients, but a more complicated

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