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CPS for Youth With Challenging Behavior

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The "Collaborative Problem Solving" model was developed by Greene for the treatment of youth with oppositional behavior, and is now called Collaborative & Proactive Solutions (CPS). The aim of CPS is to help caregivers and children practice and learn problem solving strategies in collaboration. The

Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)

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This multi-site study is intended to collect data and samples from a nationwide cohort of children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). PANS is defined by three clinical criteria: 1. Abrupt, dramatic onset of obsessive-compulsive disorder (OCD) or severely restricted food

pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD

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Cerebral Blood Flow (CBF) regulation is crucial for the adequate oxygen supply to the brain and the sustenance of cerebrovascular reserve capacity. A fundamental physiologic regulator of CBF is the carbon dioxide partial pressure (pCO2), which determines the dilatation or contraction of cerebral

Subthalamic Stimulation in Tourette's Syndrome

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Background Tourette's syndrome (TS) is characterized by the occurrence, before 18 years of age, of multiple motor and vocal tics, which do not necessarily occur concomitantly. Tics constitute the clinical hallmark of TS; they are sudden, brief, intermittent involuntary (or semi-involuntary)

Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS

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Inclusion criteria for PANDAS subjects are: - Ages 4 -40 years - Presence of DSM-IV-R obsessive compulsive disorder or tic disorder and at least two of the following: 1. Anxieties e.g. new onset separation anxiety 2. Sensory abnormalities (tactile/auditory/visual defensiveness or visual

Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission

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Study Design Overview: The goal of this study is to perform a short-term, proof of concept study to examine the safety, tolerability and efficacy of riluzole and D-serine in the treatment of tics. Each medication will be evaluated and compared to placebo as part of a randomized, double-blind,

Metformin in Amnestic Mild Cognitive Impairment

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The prevalence of Alzheimer's disease (AD) is expected to quadruple by the year 2047. There are no known curative or preventive measures for AD. Current treatment options for AD only address symptoms, and no treatments are available that focus on delaying the actual disease process. One of the

Intravenous Versus Inhalational Anesthesia in Parkinson's Disease

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We will compare the groups in terms of postoperative delirium, and cognitive and motor function changes. Patients randomized to an inhaled anesthetic will receive a standard anesthetic mix: an inhaled anesthetic with intravenous agents for rapid induction of anesthesia, narcotics for postoperative

Comparison of Keppra and Clonidine in the Treatment of Tics

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This is a randomized, double-blind, 15 week (two treatment phase), 1 week run-in, cross-over study, in which the same patient receives 6 weeks of treatment with levetiracetam and a 6 week treatment course with clonidine, separated by a two week medication wash-out. The investigators plan to enroll

Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

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OBJECTIVE The purpose of this study is to obtain a better understanding of the pathophysiology of Tourette's Syndrome (TS) with nuclear magnetic spectroscopic imaging. The basal ganglia have been implicated in the origin of tics, and we plan to use spectroscopy to determine whether there is any

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