Group of patients with postoperative delirium

Group of patients without postoperative delirium

Gene expression and expression comparison in exosomes

Spinal Disease

Eligible Surgeries: lumbar spine fusion surgery, posterior cervical spine fusion surgery, or anterior cervical spine fusion surgery

Spine surgery

College of Nursing, Yonsei University

Discovery for Biomarkers and Risk Factors for Postoperative Delirium in Elderly Patients With Spine Surgery

- Gene expression and expression comparison in exosomes The gene expression difference is determined using the SAM tool and DEseq2, and the Gene Ontology (GO) Database (www.geneontology.org) and the KEGG database (www.genome.jp/kegg) are used to find the correlation between gene functions.
In the case of miRNA, there will be a regulatory function of the coding gene, so for this purpose, an integrative analysis is performed to identify the mRNA-miRNA interaction

- EEG test for brain efficiency Peak-MEF(intermediate rhythm of background EEG spectrum), Peak-Freq, Peak_power, Theta frequency band (4 or more and less than 8) of the left (Fp1) EEG power value (log scale), Left (Fp1) EEG alpha frequency band (8 or more and less than 12) Power value (log scale), Left (Fp1) EEG slow beta band (more than 12 and less than 15) power value (log scale), Left (Fp1) EEG mid-beta frequency band (more than 15 and less than 20) power value (log scale), Fast beta frequency band of the left (Fp1) brain waves (more than 20 and less than 30) power value (log scale), Gamma frequency band (30 or more and 50 or less) power value (log scale) of left (Fp1) brain waves, Peak amplitude of 125 Hz auditory stimulated brain potential (ERP); Left and right average of P2 (maximum) peak value difference based on N1 (minimum) peak. Peak amplitude mean of left (Fp1) auditory induced brain potentials (ERPs), Left and right EEG cross-correlation coefficient.

- pulse wave test for brain efficiency HF (High Frequency) frequency band of heart rate variability (RRV) (0.15 or more and 0.4Hz or less), LF (Low Frequency) frequency band of heart rate variability (RRV) (0.04 or more and less than 0.15 Hz) absolute power, Relative percentage of LF to (LF + HF), Total power of heart rate variability (RRV), Heart rate variability (RRV) histogram; the histogram distribution area divided by the maximum value

Yonsei University

Convulsive Seizures

This study will be performed in Al-Arish Central Hospital and will include all patients from 2 months up to 18 years of age with seizures admitted to Al-Arish Central Hospital

No drug intervention

The Pattern of Pediatric Seizures at Al-Arish Central Hospital - North Sinai

Pattern of Pediatric Seizures at Al-Arish Central Hospital - North Sinai

Descriptive cross sectional study Data will be collected from patient using semi structured questionnaire through interview with patient care giver.
Data will be entered, cleaned and analyzed using statistical software program (SPSS version 20).
Descriptive statistics will be presented in the form of percentages for qualitative variables and mean and SD for quantitative data.
Qualitative data will be compared using chi-square test, and quantitative data will be compared using Student's t test, other tests will be used as appropriate .
P-value will be considered significant if less than0.05 for all statistical tests .

Ehsan M saied

Assiut

Drug: Gamunex Intravenous Immunoglobulin 2.0 gm/kg total, IV (in the vein), over 2 days

Drug: Placebo Normal saline, IV (in the vein), over 2 day

Gamunex Intravenous Immunoglobulin: 2.0 gm/kg total, IV (in the vein), over 2 days

IVIG

Placebo: Normal saline, IV (in the vein), over 2 days

Placebo

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

Higher values indicate worse severity. Seven points are possible.

Clinical Global Impressions Severity

40 points possible (i.e., range 0-40). Higher scores are more severe symptoms of OCD.

Children's Yale-Brown Obsessive Compulsive Scale Total

Active IVIG will be significantly superior to sham IVIG in reducing OC symptoms and providing global relief of neuropsychiatric symptomatology. Total score is reported as the sum of all items and has a range of 0-40. Higher scores indicate more severe symptoms.

Group A

Group B

Children's Yale-Brown Obsessive Compulsive Scale Total Score

1=very much improved, 2=much improved, 3=slightly improved, 4=no change, 5=slightly worse, 6=much worse, 7=very much worse

Clinical Global Impressions Improvement

Defined as a CGI-I score of 1 or 2 ("much" or "very much" improved) and a decrease in CY-BOCS of at least 30%

Clinical Responder to Treatment

Non-zero values of antinuclear antibodies are considered "positive" and reflective of an ongoing immune response in the individual. First, the number of participants who were classified at baseline as having "positive" antinuclear antibodies was calculated (see outcome measure data table, which states the number (AKA "count") of participants who had "positive" antinuclear antibodies at baseline). We hypothesized that improvement in the ongoing immune response, and therefore a reduction in antinuclear antibody titers, would mediate the effect of IVIG on OCD symptom improvement. However, because very few participants were classified as "positive" at baseline, it was not appropriate to pursue the original question of whether a decline in antinuclear antibodies (i.e., from "positive" to "negative") was related to symptom improvement.

The Degree of Treatment Response is Expected to Correlate With the Percentage Reduction in Antinuclear Antibody Titers Following IVIG Administration.

The Degree of Treatment Response is Also Expected to Correlate With Decreased Inflammation in Specific Regions of the Brain, as Demonstrated by Changes on MRI

Excluded prior to randomization because child did not meet study entry criteria or child refused consent

Screened But Not Randomized

Overall Study

Dr. David I. Driver

Obsessive-Compulsive Disorder

Children

Anxiety Disorder

Autoimmune Disease

PANDAS

2.0 gm/kg total, IV (in the vein), over 2 days

Gamunex Intravenous Immunoglobulin

Normal saline, IV (in the vein), over 2 days

National Institutes of Health Clinical Center, 9000 Rockville Pike

Intravenous Immunoglobulin for PANDAS

A Placebo-Controlled Trial of Intravenous Immunoglobulin (IVIG) for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections)

tics/karščiavimas

Discovery for Biomarkers and Risk Factors for Postoperative Delirium in Elderly Patients With Spine Surgery

The Pattern of Pediatric Seizures at Al-Arish Central Hospital - North Sinai

Intravenous Immunoglobulin for PANDAS

Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)

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