SLNs were tested by the OSNA assay Intraoperatively

Sentinel Lymph Node Biopsy

SLN was defatted after SLNB. If the node weighed less than 100mg, the node was only assessed by histology postoperatively. If the node weighed more than 100mg, the node was sliced to equal blocks according to the length of short axis: If the length was less than 4mm, the node was sliced into two blocks along the long axis (a, b). Intraoperatively, the block a and b were tested by TIC, and the block a was prepared for OSNA. Postoperatively, the block b was assessed by histology. If the length was more than 4mm, the node was sliced into four blocks (a, b, c, d). Intraoperatively, all blocks (a, b, c, d) were tested by TIC, and the block a and c were prepared for OSNA.

The OSNA assay

Comparative study of one-step nucleic acid amplification assay, frozen section, and touch imprint cytology for intraoperative assessment of breast sentinel lymph node in Chinese patients

Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University

Intraoperative Molecular Diagnosis of Sentinel Lymph Node In Breast Cancer Patients

The Validation Study of the Intraoperative OSNA Molecular Assay

The accuracy, sensitivity, specificity of the OSNA assay

Yongsheng Wang

Direct of Breast Cancer Center

Shandong Cancer Hospital and Institute

Twenty-seven female patients were imaged in a 3T magnet after consecutively enrolled in the study if they had received a breast cancer diagnosis at the Center for Integral Attention to Women's Health (University of Campinas) and had prescribed endovenous doxorubicin as part of their chemotherapy regimen.

Breast Cancer Female

Doxorubicin Induced Cardiomyopathy

Patients had prescribed endovenous doxorubicin as part of their chemotherapy regimen (mean cumulative dose 102,66 mg/m2, administered in 4 doses with 21 days interval).

Doxorubicin

Patients were imaged in supine position in a 3T magnet (Achieva, Philips Medical Systems, Best, The Netherlands). The protocol consisted of electrocardiographically gated cine imaging with steady state free-precession to assess left ventricular (LV) ejection fraction and LV mass. For imaging of late gadolinium-DTPA enhancement (LGE) we used an inversion-recovery-prepared, gradient-echo sequence with segmented acquisition, which was triggered every other heartbeat. LGE images were acquired during end-expiratory breath-holding, after administration of Dotarem. T1 was performed with a Look-Locker sequence with a non-slice-selective adiabatic inversion pulse, followed by segmented gradient-echo acquisition for 17 times after inversion, covering approximately two cardiac cycles. T1 imaging was repeated in the same LV short-axis slice, once before and five to seven times after the injection of gadolinium to cover an approximately 30-min period of slow contrast clearance.

Achieva, Philips Medical Systems (3T magnet)

LGE images were acquired starting within 10 min after bolus administration of a cumulative dose of 0.2 mmol/Kg of gadoterate meglumine (Dotarem, Guerbet, Aulnay-sous-Bois, France).

Gadoterate Meglumine

State University of Campinas

Doxorubicin-associated Cardiac Remodeling Followed by CMR in Breast Cancer Patients

Doxorubicin-associated Cardiac Tissue Remodeling Followed by CMR of Myocardial Extracellular Volume and Myocyte Size in Breast Cancer Patients

Estimate the extracellular volume fraction derived from gadolinium-DTPA partition Coefficient of the myocardium

This metric estimates the myocyte size using Cardiac Magnetic Resonance T1 mapping data

Electrocardiographically gated cine imaging with steady state free-precession to assess left ventricular mass.

Electrocardiographically gated cine imaging with steady state free-precession to assess left ventricular volume.

Electrocardiographically gated cine imaging with steady state free-precession to assess left ventricular ejection fraction.

Using T2-weighted sequences to visualize myocardial edema

Otavio Rizzi Coelho Filho

Professor

University of Campinas, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo

Consecutively admitted patients with pancreatic cancer confirmed by EUS-guided FNA.
EG-EUS and CE-EUS will be applied in all patients.

Consecutively admitted patients with benign pancreatic masses with negative EUS-guided FNA.
EG-EUS and CE-EUS will be applied in all patients.

Consecutively admitted patients with malignant lymphnodes confirmed by EUS-guided FNA.
EG-EUS will be applied in all patients.

Consecutively admitted patients with benign lymphnodes with negative EUS-guided FNA.
EG-EUS will be applied in all patients.

Pancreas and lymphnode samples (EUS-guided fine needle aspiration)

Pancreatic Cancer

Secondary Malignant Neoplasm of Lymph Node

Benign Neoplasm of Lymph Nodes

Benign Pancreatic Tumors

Elastography is an ultrasound method used for the reconstruction of tissue elasticity distribution in real-time. The main intended use is to differentiate between benign and malignant focal lesions based on the significantly smaller strain of the latter real time. Tissue elastography can be easily performed with conventional probes, including the linear EUS probes used for the examination of the pancreas and/or lymph nodes.
Contrast-enhancement Ultrasound contrast agents in conjunction with contrast specific imaging techniques are increasingly accepted in clinical use for diagnostic imaging. Pancreatic adenocarcinomas are usually hypovascular tumors.

Elastography, contrast enhancement

Research Center in Gastroenterology and Hepatology, University of Medicine and Pharmacy

Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes

Real-time Semi-quantification of Endoscopic Ultrasound Elastography and Contrast-enhancement Using Strain Histograms (SH) and Contrast-enhancement (CE) for the Differentiation of Focal Pancreatic Masses and the Assessment of Lymph Node Involvement

University of Medicine and Pharmacy Craiova

Institut Paoli-Calmettes

Caritas-Krankenhaus Bad Mergentheim

San Raffaele University Hospital, Italy

Tel-Aviv Sourasky Medical Center

University of Santiago de Compostela

Shengjing Hospital

Taxane-Like (Paclitaxel, Docetaxel, Abraxane, Ixabepilone)

Breast Neoplasms

Breast Cancer

Chloroquine 250mg po daily together with Paclitaxel (Taxane) 175 mg/m2 three hours infusion every three weeks.

Taxane

Chloroquine 250mg po daily together with docetaxel 75 mg/m2 administered intravenously over one hour every three weeks

Docetaxel

Chloroquine 250mg po daily together with Abraxane 260 mg/m2 administered intravenously over 30 minutes every three weeks.

Abraxane

Chloroquine 250mg po daily together with Ixabepilone is 40 mg/m2 administered intravenously over three hours every three weeks.

Ixabepilone

Houston Methodist Hospital Cancer Center

Houston Methodist Hospital Willowbrook

Houston Methodist Hospital Sugar Land

Chloroquine With Taxane Chemotherapy for Advanced or Metastatic Breast Cancer After Anthracycline Failure (CAT)

Phase II Study of The Efficacy And Safety of Chloroquine (C) in CombinAtion With Taxane or Taxane-like (T) Chemo Agents in The Treatment of Patients With Advanced or Metastatic Breast Cancer Who Have Failed Anthracycline Chemo Base Therapy.

To determine the anti-tumor activity of the combination of Chloroquine + Taxane or Taxane-like chemo agents (Paclitaxel, Docetaxel, Abraxane, Ixabepilone) (C/T) measured by overall Response Rate (ORR).

To assess the safety and tolerability of the combination of Chloroquine and Taxane or Taxane-Like chemo.

To assess the response rate and tumor control rate (TCR) of patients receiving Chloroquine + Taxane or Taxane-like.

To assess the Time to Progression (TTP) of patients receiving Chloroquine + Taxane or Taxane-like chemo.

To assess the duration of response (DOR) of patients receiving Chloroquine + Taxane or Taxane-like chemo agents.

tics/krūties vėžys

Intraoperative Molecular Diagnosis of Sentinel Lymph Node In Breast Cancer Patients

Doxorubicin-associated Cardiac Remodeling Followed by CMR in Breast Cancer Patients

Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes

Chloroquine With Taxane Chemotherapy for Advanced or Metastatic Breast Cancer After Anthracycline Failure (CAT)

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