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13 rezultatus
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery
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Prisijungti Registracija
Significance: Severe injury is a leading cause of death and disability worldwide, affecting approximately 2.8 million individuals and accounting for over 200,000 deaths annually across the United States. Large cohort studies have demonstrated that approximately 64% of trauma-related deaths are due
FMT and Fiber in Patients With Metabolic Syndrome
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Prisijungti Registracija
3.0 Design This is an exploratory four-arm, parallel design, randomized placebo-controlled intervention study in obese individuals with metabolic syndrome to evaluate whether FMT from lean donors combined with supplementation with prebiotic fiber will have a clinically significant effect on
Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome.
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Prisijungti Registracija
Phase: This is a phase II clinical trial.
Methodology: This is an exploratory, four-arm, parallel design, randomized placebo-controlled intervention study.
Study Duration: 12 weeks Study Center(s): This is a single center trial at the University of Alberta
Objectives:The objective of this study is
Trauma Induced Coagulopathy and Inflammation
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Prisijungti Registracija
A prospective, observational, convenience sample of trauma patients 18 years old or older who present to the trauma bay as a trauma alert will be included after evaluation by the on-call trauma surgeon and research assistant. Minimally injured patients will be compared to those with a systolic blood
Effects of Diet on Brain Processing
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Prisijungti Registracija
Specific Aims: In medically stable, older (> 50 years) HIV patients with cognitive impairment, this study will:
Overall: Test the feasibility of recruitment, retention, and adherence to a ketogenic diet versus patient choice diet (PCD) intervention.
Primary: Compare the impact of a 12-week KD versus
Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS
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Prisijungti Registracija
Inclusion criteria for PANDAS subjects are:
- Ages 4 -40 years
- Presence of DSM-IV-R obsessive compulsive disorder or tic disorder and at least two of the following:
1. Anxieties e.g. new onset separation anxiety
2. Sensory abnormalities (tactile/auditory/visual defensiveness or visual
Antibiotic Treatment Trial for the PANDAS/PANS Phenotype
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Prisijungti Registracija
Accumulating evidence suggests that a subset of children with obsessive compulsive disorder (OCD) have a symptom course that is temporally associated with infections (group A Streptococcus, Mycoplasma, Borrelia burgordfi, etc.). The intent of this proposal is to test the hypotheses that: 1) this
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
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Prisijungti Registracija
Background: Multiple observational studies have reported that blood product component ratios (i.e., plasma:platelets:RBCs) that approach the 1:1:1 ratio, found in fresh whole blood, are associated with significant decreases in truncal hemorrhagic death and in overall 24-hour and 30-day mortality
Intravenous Immunoglobulin for PANDAS
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Prisijungti Registracija
Objective:
This study is designed to test the safety and efficacy of intravenous immunoglobulin (IVIG) for the treatment of obsessive-compulsive disorder (OCD) symptoms in children with PANDAS (pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection).
Study
Metformin in Amnestic Mild Cognitive Impairment
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Prisijungti Registracija
The prevalence of Alzheimer's disease (AD) is expected to quadruple by the year 2047. There are no known curative or preventive measures for AD. Current treatment options for AD only address symptoms, and no treatments are available that focus on delaying the actual disease process. One of the
Neuropsychometric Outcome After Carotid Endarterectomy
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Prisijungti Registracija
Cerebral injury will be determined in four ways. First, all patients will be evaluated using a battery of neuropsychometric tests before and after surgery. Patients admitted to the Irving Clinical Research Center (CRC) will have their tests one day before, one day after surgery and at 1 month. Those
Neurological Outcome With Carotid Artery Stenting
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Prisijungti Registracija
We hypothesize that the incidence of subtle neuropsychometric injury will be significantly greater than the incidence of stroke comparable to what we found in patients having carotid endarterectomy. Patients will be evaluated prospectively to determine the incidence of neurological morbidity based
Intervention Study to Improve Adherence in Asthma
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Prisijungti Registracija
Poor adherence to the prescribed regimen of medication is one of the major obstacles to successful treatment of many chronic diseases, in the case of both grown-ups and children. In 1998 we initiated a randomized, prospective intervention study with per protocol design involving 60 young children
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