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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.

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The California bay laurel or Umbellularia californica (Hook. & Arn.) Nutt., is known as the 'headache tree' because the inhalation of its vapours can cause severe headache crises. However, the underlying mechanism of the headache precipitating properties of Umbellularia californica is unknown. The

Tolerability of the SQ Tree SLIT Tablet in Adults.

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OBJECTIVE The tree pollen sublingual immunotherapy (SLIT)-tablet (ALK, Denmark) is being developed for the treatment of tree pollen induced allergic rhinitis with or without conjunctivitis. The objective of this Phase I trial was to investigate the tolerability and acceptable dose range of the SQ

Studies on headache; analysis of the contractile state of the cranial vascular tree in migraine.

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[Identification of subgroups with lower level of stroke knowledge using decision-tree analysis].

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OBJECTIVE This study was performed to explore levels of stroke knowledge and identify subgroups with lower levels of stroke knowledge among adults in Korea. METHODS A cross-sectional survey was used and data were collected in 2012. A national sample of 990 Koreans aged 20 to 74 years participated in

Tree-in-bud Appearance in the Brain: Fungal Granuloma on Contrast Magnetic Resonance Imaging.

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We describe a case of dural-based homogenously enhancing fungal granuloma in a 29-year-old male who presented with 3 months history of headache. The peculiarity of the case was that there were streaky areas of enhancement around the lesion in the brain parenchyma which resembled tree-in-bud like

Occupational Hazards and Health and Safety Risks for Latino Tree Trimmers in the Pine Forest Industry

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A pilot project was conducted to evaluate the working conditions and work-related body pain among Latino immigrant tree trimmers (n = 57) in the commercial pine forest service industry. Participants were interviewed about personal and work characteristics, job-related occupational hazards,

Likelihood of tadalafil-associated adverse events in integrated multiclinical trial database: classification tree analysis in men with erectile dysfunction.

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OBJECTIVE To identify the patient demographic factors, comorbidities, and concomitant medications associated with a change in the likelihood of tadalafil-associated adverse events (AEs) in men with erectile dysfunction. METHODS Pooled safety data were analyzed from 3488 tadalafil-treated men who

Pleasant natural scent with unpleasant effects: cluster headache-like attacks triggered by Umbellularia californica.

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Umbellularia californica, a shrub or tree indigenous to southwestern Oregon and northern California, is commonly known as headache tree, probably because it is reported that its scent can cause headache. Here, we report the case of a 69-year-old Italian gardener, affected during his young adult age

Utility analysis of management strategies for suspected subarachnoid haemorrhage in patients with thunderclap headache with negative CT result.

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OBJECTIVE To determine the most effective follow-up strategy for evaluation of patients with thunderclap headache and negative initial non-contrast CT for acute subarachnoid haemorrhage (SAH). METHODS Institutional review was performed to assess the frequency of CT angiography (CTA) in screening

A decision support system to follow up and diagnose primary headache patients using semantically enriched data.

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BACKGROUND Headache disorders are an important health burden, having a large health-economic impact worldwide. Current treatment & follow-up processes are often archaic, creating opportunities for computer-aided and decision support systems to increase their efficiency. Existing systems are mostly

Headache and temporal arteritis: when to suspect and how to manage.

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Temporal arteritis, also termed giant cell arteritis, is one of the vasculitides affecting large and medium sized cranial arteries, particularly of the carotid tree. Clinical manifestations may vary from the classic constellation of temporal headache in the elderly accompanied by constitutional

A cortical excitatory wave may cause both the aura and the headache of migraine.

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Clinical and neurophysiological observations indicate that the symptoms of migraine aura result from the spread of an excitatory wave along the cortex from a primary focus. This excitation may start as a consequence of information overload on a low threshold cortical area. The transient neuronal

Self-reported headache frequency and features associated with frequent headaches in Canadian young adolescents.

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OBJECTIVE To explore the associated factors for frequent headache among young adolescent Canadians. METHODS We analyzed the self-administered questionnaire microdata files of the National Longitudinal Survey of Children and Youth (NLSCY: 1996 to 1997). Two thousand and ninety respondents

Subcutaneous sumatriptan in cluster headache: a time study of the effect on pain and autonomic symptoms.

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A subcutaneous injection of 6 mg sumatriptan rapidly and effectively stopped attacks of cluster headache. After a time lag of 4-14 minutes (mean 7 minutes) pain dramatically dropped to zero within seconds to single minutes (mean 56 seconds). This rapid effect may indicate that mere vasoconstriction

What clues are available for differential diagnosis of headaches in emergency settings?

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The correct diagnosis of headache disorders in an emergency room is important for developing early management strategies and determining optimal emergency room activities. This prospective clinical based study was performed in order to determine demographic and clinical clues for differential

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