Colorectal Neoplasms

Anastomotic Leak

Surgery--Complications

Colorectal resections

UOC Chirurgia Generale - Ospedale Profili - Fabriano (AN) - ASUR MARCHE AV2

UOC Chirurgia Generale - Ospedale "C. Urbani" Jesi - AV2 - ASUR Marche

UOC Chirurgia Generale e d'Urgenza - Ospedale Regionale "U. Parini" - Aosta

UOC Chirurgia Generale - Ascoli Piceno - AV5 - ASUR Marche

UOC Chirurgia Generale - San Benedetto del Tronto (AP) - AV5 - ASUR Marche

UOC Chirurgia Generale Universitaria - Ospedale San Salvatore - L'Aquila

UOC Chirurgia Oncologica - AORN San Giuseppe Moscati - Avellino

Clinica Chirurgica, Università di Brescia - UOC Chirurgia Generale 3, ASST Spedali Civili di Brescia - Brescia

UOC Chirurgia Generale - Ospedale Montichiari (BS) - ASST Spedali Civili di Brescia

S.C. Chirurgia Generale e Oncologica - Azienda Ospedaliera S. Croce e Carle - Cuneo, Italia

UOC Chirurgia Generale 1 - Chirurgia laparoscopica - Università di Ferrara

UOC di Chirurgia Addominale IRCCS Casa Sollievo della Sofferenza - San Giovanni Rotondo - Foggia

UOC Chirurgia Generale - Ospedale S. Maria Annunziata - Firenze - ASL Toscana Centro

UOC Chirurgia Generale ad Indirizzo Oncologico - IRCCS San Martino IST - Genova

UOC Chirurgia Generale - Ospedale"San Giovanni di Dio", ASP di Crotone (KR)

UOC Chirurgia Generale e d'Urgenza - Ospedale Cardinale Panico - Tricase (LE)

UOC Chirurgia Generale - ASST Nord - Sesto San Giovanni (MI)

UOC Chirurgia Generale - Ospedale di Esine (BS) - ASST Valcamonica

UOC Chirurgia Generale e D'Urgenza - Pescara

UOC Chirurgia Generale - Foligno (PG) - USL UMBRIA 2

SC Chirurgia Generale e Oncologica - AO Marche Nord - Pesaro

UOC Chirurgia Generale - Ragusa

UOC Chirurgia Generale - Ospedale "Regina Apostolorum" Albano Laziale (RM)

UOC Chirurgia Generale e d'Urgenza - Policlinico Casilino - Roma

UOC Chirurgia Generale e D'Urgenza . Azienda Ospedaliera San Camillo Forlanini Roma

UOC Chirurgia Generale e Oncologica - Ospedale San Filippo Neri - ASL Roma1

UOS Chirurgia Geriatrica - Università Campus BioMedico - Roma

UOSD Chirurgia Mininvasiva e dell'Apparato Digerente - Università Tor Vergata - Roma

UOC Chirurgia Generale, Ospedale "Ceccarini" di Riccione (RN)

UOC Chirurgia Generale e d'urgenza, Rimini, Novafeltria, Santarcangelo

UOC Chirurgia Generale I - Ospedale di La Spezia - ASL5 Spezzino

UOC Chirurgia Generale 1 - Ospedale S. Chiara - APSS Trento

UOC Chirurgia Generale e Mininvasiva, Ospedale San Camillo di Trento

UOC Chirurgia Generale - Ospedale "E. Agnelli" di Pinerolo (TO) - ASL TO3

UOC Chirurgia Generale - Conegliano Veneto (TV) AULSS2 Marca trevigiana

UOC Chirurgia Generale - Ospedale Sacro Cuore Don Calabria Negrar Verona

U.O.C. di Chirurgia Generale e dell'Esofago e Stomaco - AOUI di Verona

UOC Chirurgia Generale Epatobiliare - AOUI Verona

UOC Chirurgia Generale Oncologica - Azienda Ospedaliera Belcolle - Viterbo

SOC Chirurgia Colorettale - Istituto Nazionale dei Tumori - IRCCS Fondazione "G.Pascale" - Napoli

UOC Chirurgia Generale - Pozzuoli (NA) - ASL Napoli2 nord

Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery

Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery: the Italian ColoRectal Anastomotic Leakage Study Group (iCral 2)

Rate of any complication related to the anastomosis after colorectal resection

Rate of any complication after colorectal resection

Rate of any death after colorectal resection

Rate of any unplanned readmission after discharge

number of days between primary colorectal resection and discharge

Marco Catarci

Director, General Surgery Unit

Ospedale C & G Mazzoni

Participants consuming leucine supplementation with measures obtained from the uni-laterally immobilised leg.

Participants consuming leucine supplementation with measures obtained from the non-immobilised leg.

Participants consuming placebo supplementation with measures obtained from the uni-laterally immobilised leg.

Participants consuming placebo supplementation with measures obtained from the non-immobilised leg.

Muscle Disuse Atrophy

Participants will ingest 15g of leucine supplementation/day during the immobilisation period. Leucine supplementation will be administered in powdered form (Infinit Nutrition, Canada) and participants will be required to consume 5g of leucine mixed with 250-300 ml of water during each meal. Leucine is a dietary supplement according to the US FDA. This supplementation protocol has been demonstrated in humans (Murphy et al., 2016, AJCN) with no reported side effects. The quantity of leucine supplementation falls well within the safe limits outlined by Rasmussen et al. (2016). Infinit Nutrition Leucine is in compliance with banned substances requirements as espoused by the World Anti-Doping Agency. Infinit Nutrition Leucine is not a medicinal product.

Leucine

Participants will ingest 15g of placebo supplementation/day during the immobilisation period. Placebo supplementation will be administered in powdered form and participants will be required to consume 5g of placebo supplementation mixed with 250-300 ml of water during each meal (3x/day).
Placebo supplementation will contain 5g of non-essential amino acids (Infinit Nutrition, Canada) and will be calorically matched to the leucine supplementation.This supplementation protocol has been demonstrated previously in humans, with no reported side effects (Murphy et al., 2016, AJCN).

Placebo

University of Birmingham, School of Sport, Exercise and Rehabilitation Sciences

Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?

The change in the lean mass of the leg muscles following the 7 day immobilisation period.

The rates of post-absorptive and post-prandial myofibrillar protein synthesis response to 20 g of milk protein after a 7 day period of disuse.

University of Birmingham

16 old participants (55-65 years) were included in physical inactivity or bed rest with supervised recovery intervent and underwent 14-day of bed rest. Bed rest was followed by 28-day recovery. During the bed rest participants will remain 24-hour horizontal with all daily activities performed lying in a bed. No social isolation will be forced. During the recovery participants will 3-times weekly per 75 minutes perform guided exercises to achieve baseline level.

7 young participants (18-30 years) were included in physical inactivity or bed rest with supervised recovery intervent and underwent 14-day of bed rest. Bed rest was followed by 28-day recovery. During the bed rest participants will remain 24-hour horizontal with all daily activities performed lying in a bed. No social isolation will be forced. During the recovery participants will 3-times weekly per 75 minutes perform guided exercises to achieve baseline level.

Muscular Atrophy

All (older and younger) participants underwent 14 day of horizontal bed rest with all 24 hour daily activities were performed lying in a bed. Maximal one pillow was allowed. 28-day supervised recovery was performed 3 times weekly for 75 minutes/session.

physical inactivity or bed rest with supervised recovery

Orthopaedic Hospital Valdoltra

Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants

CB147 - Physical Activity and Nutrition for Quality Ageing

Using MRI continous screening of single leg was performed

Biopsy samples were obtained from vastus lateralis muscles

graded cycling on sitting ergometer until exhaustion

Estimated from single leg isometric maximal voluntary contraction

estimated from bilateral efforts on explosive ergometer (EXER)

Walking through the food placement detection system

collected hourly for 6 hours after standard meal load as a measure of insulin sensitivity index

collected hourly for 3 hours after standard meal load

From Tensiomyographic response in vastus lateralis

The data is shared among partners for various publications

University of Primorska

University of Trieste

University of Udine

University of Padova

Università degli Studi di Ferrara

University of Nottingham

DLR German Aerospace Center

Izola General hospital

National Institute of Public Health, Slovenia

Injection, 500 mg, single use, over 15 to 20 minutes.

In Control arm, patients will receive the standardized surgical treatment without receiving methylprednisolone preoperatively (placebo).

Complications

Patients in Methylprednisolone arm will receive injection methylprednisolone 500 mg I/V over 15 to 20 minutes, single dose, 30 minutes before starting surgery.

Methylprednisolone

Patients in the placebo group will receive standard perioperative care and surgery, without preoperative administration of methylprednisolone.

venous thrombosis/carbohydrate

Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery

Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?

Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants

Preoperative Glucocorticoid Use in Major Hepatectomy

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