Effect of dialysis on the clearance of Staphylococcus epidermidis from the peritoneal cavity: an experimental evaluation.

Current information on the effect of peritoneal dialysis on host defenses in the peritoneal cavity is limited to in vitro studies. In the present study, clearance of Staphylococcus epidermidis from the abdominal cavity was assessed in an animal model undergoing peritoneal dialysis. In non-manipulated subjects, challenges of up to 10(8) viable microorganisms were cleared from the peritoneal cavity over a period of 24-48 hours. Cannula implantation, short- and long-term dialysis and the presence of excessive amounts of fluid in the peritoneal cavity did not affect the clearance rate. Presentation of the bacterial challenge, either as a bolus or via a slow delivery system, likewise had no effect on clearance rates. The results suggest that microbial trophism and the characteristics of the invading pathogen may be more critical determinants of the outcome of an infectious challenge to the peritoneal cavity than the status of the cellular and humoral defense systems.