Effects of lutein from marigold extract on immunity and growth of mammary tumors in mice.
Atslēgvārdi
Abstrakts
The effects of dietary lutein from marigold extract on the development and growth of a transplantable murine mammary tumor and on lymphocyte function were investigated. Mice were fed a diet containing 0.1% or 0.4% of lutein. In experiment 1, mice were fed the diets for 3 weeks and infused with mammary tumor cells into the mammary gland. Dietary lutein increased tumor latency and inhibited mammary tumor growth in a dose-dependent manner. The incidence of palpable tumors on day 28 post-infusion and final tumor weight were lower in mice fed lutein. In experiment 2, dietary lutein enhanced phytohemagglutinin-induced lymphocyte proliferation but had no effect on interleukin-2 production or lymphocyte cytotoxicity. Therefore dietary lutein increased tumor latency, suppressed mammary tumor growth and enhanced lymphocyte proliferation.