γ-Glutamyl transferase activity and the burden of coronary atherosclerosis in patients with ST-segment elevation myocardial infarction.

The relationship between extent, severity, and complexity of coronary artery disease (CAD) in patients with ST-segment elevation myocardial infarction (STEMI) and serum γ-glutamyl transferase (GGT) activity has not been adequately studied. We evaluated the relationship between GGT activity and the burden of CAD as assessed by SYNTAX score (SXscore) in patients with STEMI. A total of 243 patients (age 67.1 ± 8.6, 77.4% male) with STEMI were divided into 2 groups. Low- and high-SXscore groups were defined as SXscore <22 and ≥22, respectively. Admission GGT activities were similar between low- and high-SXscore groups (32 ± 17 vs 33 ± 18; P = .625), and there was no significant correlation between GGT activity and SXscore. Although there was an association between high SXscore and major adverse cardiovascular events, as expected, our results did not demonstrate any relationship between admission GGT activities and complexity and extent of the coronary lesions in patients with STEMI.