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amide/fatigue

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More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine.

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Ielogoties Reģistrēties
Amphetamine is a stimulant drug that enhances attention and feelings of alertness. Amphetamine's effects are known to be modulated by endogenous cannabinoids, which are degraded by the enzyme fatty acid amide hydrolase (FAAH). In this study we investigated inter-individual differences in mood

[Amide groups of brain and spinal proteins in acute and chronic alcohol intoxication].

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Ielogoties Reģistrēties
Acute and chronic alcohol intoxication causes a considerable deamidation of central nervous system proteins which is most pronounced in the spinal cord. There occurs rearrangement in the amide bonds lability and in the ratio of easy-hydrolyzable and strongly bound amide groups. The metabolic

Mechanisms of bioprosthetic heart valve failure: fatigue causes collagen denaturation and glycosaminoglycan loss.

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Ielogoties Reģistrēties
Bioprosthetic heart valve (BPHV) degeneration, characterized by extracellular matrix deterioration, remodeling, and calcification, is an important clinical problem accounting for thousands of surgeries annually. Here we report for the first time, in a series of in vitro accelerated fatigue studies
BACKGROUND Generally, nails can be an index of health, with abnormalities sometimes found under diseased conditions. Fatigue is also supposed to affect the condition of nails. Possible differences in infrared (IR) spectra of nail plates of chronic fatigue syndrome (CFS) patients compared to healthy

Amide- and urea-functionalized dithienylethene: synthesis, photochromism, and binding with halide anions.

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Ielogoties Reģistrēties
A versatile amide- and urea-functionalized dithienylethene has been successfully synthesized. Upon irradiation with UV or visible light, the compound showed excellent fatigue resistance. As a synthetic receptor, the dithienylethene displayed switchable affinities for Cl(-) and Br(-) anions when the

Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue.

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Ielogoties Reģistrēties
Reactions involving thiol biochemistry seem to play a crucial role in skeletal muscle fatigue. N-acetylcysteine amide (NACA) and L-ergothioneine (ERGO) are thiol-based antioxidants available for human use that have not been evaluated for effects on muscle fatigue. OBJECTIVE To test the hypothesis
Selective human serotonin reuptake transporter (hSERT) inhibition is the first line of treatment to deal with the depression. In clinical practice for managing depression, the stimulants are co-prescribed to overcome cognitive impairment and fatigue. Recently, histamine H(3) antagonists with

Analysis of lysergic acid amide in human serum and urine after ingestion of Argyreia nervosa seeds.

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Ielogoties Reģistrēties
The ergot alkaloid lysergic acid amide (LSA) is a secondary plant constituent in a number of plants, but it is mainly present in considerable amounts in Convolvulaceae, like Argyreia nervosa. Due to its close structural similarity to lysergic acid diethylamide, LSA is considered as psychedelic and

Cobalt Amide Imidate Imidazolate Frameworks as Highly Active Oxygen Evolution Model Materials.

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Ielogoties Reģistrēties
Two imidazolate-based Co-MOFs, IFP-5 and IFP-8 (imidazolate framework Potsdam), with a different peripheral group -R (-Me and -OMe, respectively) have been synthesized by a solvothermal method and tested toward the oxygen evolution reaction (OER). Remarkably, IFP-8 presents much lower overpotentials

[Phase-II-study with vindesine (desacetyl-vinblastine-amide-sulfate) in advanced malignant diseases].

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Ielogoties Reģistrēties
53 patients with advanced and measurable cancerr were treated with vindesine in doses of 3 mg/m2 (pretreated) and 4 mg/m2 (non pretreated) i.v. once weekly. 48 patients are evaluable for response: of 14 patients with squamous cell carcinoma of the lung, 1 partial remission (PR), 1 minor response

The potential role of B5: A stitch in time and switch in cytokine.

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Ielogoties Reģistrēties
The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic

Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex.

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Ielogoties Reģistrēties
Photochromic molecules are widely applied in chemistry, physics, biology, and materials science. Although a few photochromic systems have been developed before, their applications are still limited by complicated synthesis, low fatigue resistance, or incomplete light conversion. Rhodamine is a class
Multiple myeloma is a blood cell cancer and can cause symptoms such as bone loss and fatigue. Recent studies have shown that the bone marrow microenvironment may mediate tumor proliferation, drug resistance, and migration of the multiple myeloma cells. Synthetic triterpenoids have been used for the

Low doses of arginine butyrate derivatives improve dystrophic phenotype and restore membrane integrity in DMD models.

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Ielogoties Reģistrēties
A new approach to treating Duchenne muscular dystrophy was investigated by using the ester or amide covalent association of arginine [nitric oxide (NO) pathway] and butyrate [histone deacetylase (HDAC) inhibition] in mdx mice and patient myotubes. Two prodrugs were synthesized, and the beneficial

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection

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Ielogoties Reģistrēties
Fibromyalgia is a rheumatologic condition characterized by multiple and chronic body pain, and other typical symptoms such as intense fatigue, anxiety and depression. It is a very complex disease where treatment is often made by non-medicated alternatives in order to alleviate symptoms and improve
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