amide/galvassāpes

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Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders

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Ielogoties Reģistrēties

Throughout this application, various references are referenced by short citations within parenthesis. Full citations for these references may be found at the end of the specification, immediately preceding the claims. These references, in their entireties, are hereby incorporated by reference to

Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis

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Ielogoties Reģistrēties

This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals. UK Patent Applications, GB Nos. 2100259A and 2125398A describe benzoates and

Use of a vitamin combination for the treatment of primary headaches

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Ielogoties Reģistrēties

The present invention concerns the use of a vitamin combination for the treatment of primary headaches. More particularly, this invention relates to the use of a combination of two vitamin compounds, i.e. riboflavin (also known as vitamin B.sub.2) and nicotinic acid (also referred to as niacin) or,

Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity

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Ielogoties Reģistrēties

BACKGROUND OF THE PRESENT INVENTION The present invention is novel compounds, which are derivatives of hydroxybenzylamine and as such are related to capsaicin. The present compounds have antiinflammatory activity for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel

Aromatic and heteroaromatic substituted amides

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FIELD OF INVENTION The invention relates to a compound of formula ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen and fluoro. Compounds of formula 1, and pharmaceutically acceptable acid addition salts thereof, have been shown to mediate the Neurokinin 1 (NK-1, substance

L-N.sup.5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof

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Ielogoties Reģistrēties

TECHNICAL FIELD The invention is directed at certain ornithine and lysine derivatives which are selective, mechanism-based inactivators of neuronal isoform of nitric oxide synthase and selective inhibitors of nitric oxide synthase. BACKGROUND OF THE INVENTION Nitric oxide synthase (NOS) catalyzes

Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them

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Ielogoties Reģistrēties

FIELD OF THE INVENTION The present invention generally relates to propylisopropyl acetic acid (PIA) and propylisopropyl acetamide (PID) in their racemic and stereospecific forms, to some of their isomers and to stereoisomers thereof, for use in treatment of neurological and psychotic disorders, and

Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them

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Ielogoties Reģistrēties

Benzamide derivative or salt thereof

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Ielogoties Reģistrēties

CROSS REFERENCE TO RELATED APPLICATION This application is a 371 of PCT/JP04/008479, filed on Jun. 10, 2004, and claims priority to the following applications: Japanese Patent Application No. 2003-167865, filed on Jun. 12, 2003 and Japanese Patent Application No. 2003-405086, filed on Dec. 3,

Benzamide derivative or salt thereof

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Ielogoties Reģistrēties

TECHNICAL FIELDS The present invention relates to novel benzamide derivatives or salts thereof useful as medicaments, particularly, capsaicin receptor VR1 (Vanilloid Receptor 1) activation inhibitor, and the medicaments. BACKGROUND ART Capsaicin, which is a main component of chili pepper, is an

Vanilloid receptor ligands and their use in treatments

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Ielogoties Reģistrēties

BACKGROUND The vanilloid receptor 1 (VR1) is the molecular target of capsaicin, the active ingredient in hot peppers. Julius et al. reported the molecular cloning of VR1 (Caterina et al., 1997). VR1 is a non-selective cation channel which is activated or sensitized by a series of different stimuli

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