analgesic/insults

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Lappuse 1 no 17 rezultātiem

Method and composition for potentiating the antipyretic action of a nonopioid analgesic

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Ielogoties Reģistrēties

FIELD OF THE INVENTION The present invention relates to the treatment of fever using a nonopioid analgesic and an endothelin antagonist. More particularly, the present invention relates to a method of potentiating the antipyretic action of a nonopioid analgesic, like acetaminophen, in a mammal by

Simplified resiniferatoxin analogues as vanilloid receptor agonist showing excellent analgesic activity and the pharmaceutical compositions containing the same

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Ielogoties Reģistrēties

FIELD OF THE INVENTION The present invention relates to vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and methods of using such analogues as vanilloid receptor agonists and potent analgesics. BACKGROUND OF THE INVENTION As

Compositions having neuroprotective and analgesic activity

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Ielogoties Reģistrēties

FIELD OF THE INVENTION This invention involves means for treating neuronal injury and achieving analgesia by administration of compositions containing compounds of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are alkyl having 1-8 carbon atoms. BACKGROUND OF THE INVENTION Compounds having an

4-(methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same

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Ielogoties Reģistrēties

TECHNICAL FIELD The present invention relates to novel 4-(methylsulfonylamino)phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same. BACKGROUND ART The vanilloid receptor (VR1) is a member of the transient receptor

Compositions having neuroprotective and analgesic activity

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Ielogoties Reģistrēties

.alpha.-conotoxin peptides with analgesic properties

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Ielogoties Reģistrēties

This invention relates to novel peptides of the alpha conotoxin (.alpha.-conotoxin) class and their use in the treatment or prevention of pain, in recovery from nerve injury and in the treatment of painful neurological conditions such as stroke. The invention also relates to pharmaceutical

N-benzylaniline derivative and uses thereof

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Ielogoties Reģistrēties

This application is the U.S. National Phase under 35 U.S.C. .sctn.371 of International Application No. PCT/CN2012/083455, filed Oct. 24, 2012, designating the U.S., and published in Chinese as WO 2013/064031 on May 10, 2013, which claims priority to Chinese Patent Application No. 201110343293.X,

Aryl (ethanoic) propanoic acid ascorbyl ester, preparation method thereof and medicament containing the same

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Ielogoties Reģistrēties

CROSS REFERENCE TO RELATED PATENT APPLICATION The present application is the US national stage of PCT/CN2009/075994 filed on Dec. 24, 2009, which claims the priority of the Chinese patent application No. 200910026697.9 filed on May 11, 2009, which application is incorporated herein by

Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same

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Ielogoties Reģistrēties

TECHNICAL FIELD The present invention relates to a novel biaryl benzoimidazole derivative, a method for preparing the same, and a pharmaceutical composition comprising the same, in which the biaryl benzoimidazole derivative functions as an antagonist of the vanilloid receptor (Capsaicin receptor;

Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases

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Ielogoties Reģistrēties

FIELD OF THE INVENTION This invention relates to compounds useful as neuroprotectants, anticonvulsants, anxiolytics, analgesics, muscle relaxants or adjuvants to general anesthetics. The invention relates as well to methods useful for treatment of neurological disorders and diseases, including, but

(4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides

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Ielogoties Reģistrēties

BACKGROUND OF THE INVENTION The present invention relates to (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment. The compounds of the present invention are inhibitors of zinc metalloendopeptidases, especially

Crystalline anhydrous and monohydrate benzoate salts of (2'S,3S)-3-hydroxy-N-(2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amin- o-2-phenyl)-ethylpyrrolidine

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Ielogoties Reģistrēties

FIELD OF THE INVENTION This invention relates to crystalline anhydrous and monohydrate benzoate salts of (2'S,3S)-3-hydroxy-N-{2-[N-methyl-N-4-(N-propylamino-carbonyl)ph- enyl]amino-2-phenyl}-ethylpyrrolidine, processes for preparing and using them. The pharmaceutically active salts of this

Use of conantokins

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Ielogoties Reģistrēties

BACKGROUND OF THE INVENTION The invention relates to the use of relatively short peptides, about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which include preferably one to two or more

Use of conantokins

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Ielogoties Reģistrēties

BACKGROUND OF THE INVENTION The invention relates to the use of relatively short peptides, about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturaly available peptides, and which include preferably one to two or more

Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof

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Ielogoties Reģistrēties

FIELD OF THE INVENTION The present invention relates to therapeutically active quinolinic sulfide derivatives acting as potent and specific antagonists of excitatory amino acids, to a process for preparation and to their use in treatment in neurological disorders. Particularly, the compounds

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