will receive single intravesical dose of epirubicin intravesical therapy (50 mg) within 48 hours of radical nephroureterectomy with open bladder cuff excision.

will receive a single intravesical dose of epirubicin and an additional 6 weekly doses of intravesical therapy (50 mg) after surgery then monthly maintenance therapy for 1 year.

Neoplasm, Ureter

Neoplasm, Bladder

Immediate instillation of intravesical chemotherapy-Epirubicin-

Maintainance therapy of intravesical chemotherapy-Epirubicin-

Urology and Nephrology Center

Prophylactic Intravesical Chemotherapy After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: a Randomized Controlled Trial Between Single Postoperative Dose Versus Maintenance Therapy.

The primary outcome of the study is the diagnosis of intravesical recurrence within the first year after surgery.

The secondary outcome is to determine the adverse events postoperative morbidity, mortality and survival of patients with UTUC.

Magdy Elshabrawy

Fellow in Urology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Mansoura University

Soft Tissue Sarcoma

Sunitinib dose 50 mg/day orally for 2 weeks prior to radiotherapy. Treatment Dose Levels during radiotherapy: Dose level 0: Sunitinib 50mg/day for 2 weeks prior to radiotherapy, followed by 25mg/day given concurrently with radiotherapy; Dose level 1: Sunitinib 50mg/day for 2 weeks prior to radiotherapy, followed by 37.5mg/day given concurrently with radiotherapy; Dose level -1: Sunitinib 37.5mg/day for 2 weeks prior to radiotherapy, followed by 37.5mg/day given concurrently with radiotherapy. Dose escalation/de-escalation: first 6 patients will be accrued at dose level 0. The dose levels at which subsequent patients will be accrued will be determined using a dose modification schedule.

Sunitinib malate

Preoperative radiotherapy consisting of external beam radiotherapy at a dose of 50.4 Gy given in 28 fractions, five days a week, over five weeks and 3 days to the planning target volume.

arabinoside/necrosis

Prophylactic Intravesical Chemotherapy After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: a Randomized Controlled Trial Between Single Postoperative Dose Versus Maintenance Therapy.

Sunitinib and Radiation in Patients With Resectable Soft-tissue Sarcoma

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