bone resorption/albumin

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Novel Combination Therapy for Osteoporosis in Men

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Ielogoties Reģistrēties

NOVEL COMBINATION THERAPY FOR OSTEOPOROSIS IN MEN 1. Background for the Study What Is the Risk of Osteoporotic Fractures in Men and Why Do Men Lose Bone Mass? Osteoporosis is a neglected condition in men. Yet, men sustain approximately 30% of the 1.5 million fractures that occur annually in the US.

Vitamin D Supplementation in the Armed Forces

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Ielogoties Reģistrēties

Study Overview: Aim: The effect of vitamin D3 supplementation in (male) Royal Marine recruits during 32-weeks of (arduous) initial military training on stress fracture and respiratory illness risk. Volunteer recruits will initially complete a healthy history, smoking habit and alcohol consumption

Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid

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Ielogoties Reģistrēties

Glucocorticoids have direct effects on bone remodeling by suppressing bone formation (inhibition of osteoblastic differentiation, inhibition of mature osteoblasts function and apoptosis of mature osteoblasts) and by increasing bone resorption (decrease in osteoclast apoptosis and stimulation of

Metabolic Complications Following Knee Injury in Young and Middle Aged Patients

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Ielogoties Reģistrēties

Hypothesis Implementation of a sedentary lifestyle with almost no physical activity in otherwise physical active individuals undergoing knee orthopaedic surgical procedures will during 6 weeks (4 to 8 weeks) - derange insulin sensitivity and glucose effectiveness - decrease disposition index - imply

Metabolic Complications Following Achilles Tendon Rupture - A Cohort Study

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Ielogoties Reģistrēties

Introduction This study will evaluate the effect on glucose, lipid and bone metabolism following conservative orthopaedic procedures in patients who suffered from acute Achilles tendon rupture. The sedentary rehabilitation period following these procedures may impact negatively upon glucose, lipid

The Efficacy of Denosumab in Active Crohn's Disease

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Ielogoties Reģistrēties

1.0 Hypothesis Moderate to severely active Crohn's disease (CD) will respond to treatment with Denosumab, (a monoclonal antibody to Receptor Activator of Nuclear factor-Kappa B ligand (RANKL) The principal research questions to be addressed: 1. Determine if a single dose of Denosumab can induce a

Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism

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Ielogoties Reģistrēties

Introduction: Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder, after diabetes mellitus and thyroid disorders, that predominantly affects postmenopausal women, with an incidence of 1 -5 in 1000 people. It can occur at any age though young people are rarely affected.

African-American Bone Metabolism and Lactation Study

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Ielogoties Reģistrēties

Pregnancy and lactation are both states of altered maternal calcium and bone metabolism which may have a significant impact on the development of peak bone mass. While these two states are characterized by different hormonal environments, both have been associated with significant bone loss. The

An Open-label Phase II Study With SUTENT in Patients Suffering From Hormone Refractory Prostate Cancer

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Ielogoties Reģistrēties

- Antitumor efficacy of sunitinib will be assessed as follows: - PSA response rate and PSA progression according Working Group Criteria, - Variation of PSA doubling time (PSADT) before and after initiation of the treatment, - Objective response rate (ORR) according to RECIST criteria, - Clinical

The Effect of Vitamin D and Calcium on Bone in Pediatric HIV

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Ielogoties Reģistrēties

A.1.a. Introduction This is a prospective, randomized, double-blind clinical trial designed to evaluate the effect of 24 months of supplementation with vitamin D3 and calcium on bone mass accrual in HIV-infected children and adolescents. A.1.b. Subject recruitment i. HIV-infected subjects on will be

The Effects of Alendronate After Cure of Primary Hyperparathyroidism

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Ielogoties Reģistrēties

Study Purpose: Hypothesis: After successful surgical cure of primary hyperparathyroidism alendronate provides even greater beneficial skeletal effects than parathyroidectomy alone. Primary hyperparathyroidism (PHPT) is typically a disorder of mild hypercalcemia. Skeletal involvement can be

The Effects of Potassium Citrate on Bone Metabolism

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Ielogoties Reģistrēties

Participants were recruited from a single academic center. Subjects underwent screening at the Clinical Translational Science Center (CTSC) at Weill Cornell Medical College (WCMC). Study visits occurred at the CTSC where investigators administered and monitored questionnaires, compliance, adverse

The FREEDOM Study: a Randomised Controlled Trial of Sunlight and Calcium in Older People

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Ielogoties Reģistrēties

Specific Aims and Objectives The proposed trial will determine the effect of a public health strategy (ie increased sun light exposure and increased calcium intake) to reduce falls and fractures in older people living in residential care in a randomised trial. The primary hypothesis of the trial is

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