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carcinogenesis/nelabums

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Effect of the CYP2C19 Polymorphism in Helicobacter Pylori Eradication

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Ielogoties Reģistrēties
Introduction: H. pylori has been declared and ratified as carcinogen I by the World health organization (WHO) International agency for research on cancer (IARC). Globally first line therapy eradication treatment recommended for H. pylori, combines a proton-pump inhibitor (PPI) with two antibiotics

Assessing Toxicity of Waterpipe Tobacco Smoking

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Ielogoties Reģistrēties
Globally, 1 in 3 adults or 1.2 billion people smoke. The World Health Organization (WHO) estimated that tobacco is responsible for the death of 1 in 10 adults worldwide, about 6 million premature deaths each year. In the United States (U.S.), cigarette smoking is responsible for more than 480,000

Fiber to Reduce Colon Cancer in Alaska Native People

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Ielogoties Reģistrēties
Randomization for the double blind, placebo controlled, clinical trial: Recruitment will continue until 60 volunteers have completed the intervention study. Based on previous experience with similar studies, we anticipate 20% of screened patients to be ineligible or drop out, which means, so we plan

Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors

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Ielogoties Reģistrēties
The role of the proteasome in carcinogenesis and cell survival has been well established, and its inhibition associated with an accumulation of pro-apoptotic proteins and cell death. Proteasome inhibitors, such has bortezomib, have been extensively studied and are widely used as effective therapy in

A Trial of Iron Replacement in Patients With Iron Deficiency.

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Ielogoties Reģistrēties
1.1 Literature Iron deficiency anemia is a common and a major management issue in Inflammatory Bowel disease [1-3]. Moreover, no factor has been identified in predicting recurrent iron deficiency anemia [4]. Iron deficiency and anemia are well recognized causes of fatigue, poor concentration and

Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism

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Ielogoties Reģistrēties
Approximately 32 subjects will be enrolled in ascending dosing cohorts of 8 subjects each. Each subject will receive an oral dose of study drug (fomepizole or placebo) with concomitant ethanol with group assignment in a randomized 1:1:1:1 ratio (2 subjects each group) on Study Day 1. Each subject is

Transplantation of Umbilical Cord Blood Following Chemotherapy for Blood Cancers

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Ielogoties Reģistrēties
The success of BMT as a curative option for patients with malignancies is frequently limited by the inability to identify an appropriate donor in time for transplantation. Transplantations utilizing umbilical cord blood stem cells are increasingly successful. Data suggest that there are fewer and
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