BOT ovarian tissue presenting with non-invasive implants

BOT ovarian tissue presenting with micropapillary grow pattern

sBOT ovarian tissue presenting with invasive implants at the time of diagnosis

Macrodissection of borderline ovarian tumor tissue. DNA extraction from paraffin embedded material for genetic analysis.

Ovarian Neoplasm Epithelial

Sequencing of the DNA samples extracted from the subgroups
serous BOT tissue,
serous BOT tissue with non-invasive implants and
serous BOT tissue with micropapillary grow pattern will undergo a panel testing for Type 1 genes (small panel 15-40 mutations) AND p53 AND BRCA testing
Sequencing of the DNA samples extracted from the serous BOT tissue with invasive implants will undergo a more comprehensive examination (large panel +- 1000 genes checked)

genomic mutations study

Sub-type Specific Genomic Mutations in sBOTs

Sub-type Specific Genomic Mutations in Serous Borderline Ovarian Tumors

amount and type of genetic mutations in different subgroups will be analyzed and compared between the different subgroups. Are the mutations suggestive for a type I or type II pathway differentiation?

Stefan Cosyns

Principal Investigator

Universitair Ziekenhuis Brussel

Patients follow a regular diet for 4-6 weeks and then undergo prostatectomy.

Patients follow a low polyphenol diet for 4-6 weeks and then undergo prostatectomy.

Patients follow a low ellagitannin diet for 4-6 weeks and then undergo prostatectomy.

Patients follow a low ellagitannin diet and receive lower-dose black raspberry gummy PO daily for 4-6 weeks and then undergo prostatectomy.

Patients follow a low ellagitannin diet and receive higher-dose black raspberry gummy PO daily for 4-6 weeks and then undergo prostatectomy.

Patients follow a low ellagitannin diet and receive lower-dose black raspberry confection PO daily for 4-6 weeks and then undergo prostatectomy.

Patients follow a low ellagitannin diet and receive higher-dose black raspberry confection PO daily for 4-6 weeks and then undergo prostatectomy.

Stage I Prostate Cancer

Stage IIA Prostate Cancer

Stage IIB Prostate Cancer

Stage III Prostate Cancer

lyophilized black raspberry confection

laboratory biomarker analysis

dietary intervention

quality-of-life assessment

questionnaire administration

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center

Aborption and Metabolism of Lyophilized Black Raspberry Food Products in Men With Prostate Cancer Undergoing Surgery

Dietary Fruit Bioactives and Prostate Cancer

A cohort will be considered compliant if the group mean consumption of the intervention product is at least 80%.

Analyzed on the log scale using a repeated measures linear model to judge the effect of treatment group in terms of fold-differences from baseline while controlling for body mass index (BMI) and age. Confidence intervals for dichotomous variables will be made using exact methods and confidence intervals for rank correlations between quantitative variables will be made using Fisher's transformation.

Analyzed on the log scale using a repeated measures linear model to judge the effect of treatment group in terms of fold-differences from baseline while controlling for BMI and age. Confidence intervals for dichotomous variables will be made using exact methods and confidence intervals for rank correlations between quantitative variables will be made using Fisher's transformation.

Confidence intervals for dichotomous variables will be made using exact methods and confidence intervals for rank correlations between quantitative variables will be made using Fisher's transformation.

carcinogenesis/phosphatase

Sub-type Specific Genomic Mutations in sBOTs

Aborption and Metabolism of Lyophilized Black Raspberry Food Products in Men With Prostate Cancer Undergoing Surgery

Effects of Tomato-Soy Juice on Biomarkers in Patients With Prostate Cancer Undergoing Prostatectomy

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