Patients on hemodialysis who consumed one month Standardized Aronia Melanocrpa extract

Renal Disease

Dialysis; Complications

Anemia

During 30 days all patients take every day 30ml of Alixir 400 protect

Alixir 400 Protect

Faculty of Medical Science

The Effects of One Month Consumption of Standardized Aronia Melanocarpa Extract on Anemia in Patients on Hemodialysis

The Effects of One Month Consumption of Standardized Aronia Melanocarpa Extract on Anemia in Patients on Hemodialysis: Focus on Oxidative Stress and Inflammation

Superoxide anion radical, Hydrogen peroxide, Nitrites Units nmol/ml

Superoxide dismutase, Catalase Units U/g Hb x 1000

Reduced glutathione Unit nmol/l RBC x 1000

The parameters of inflammation CRP Unit mg/l

The parameters of inflammation TNF alpha Unit pg/ml

The parameters of inflammation white blood cells Unit x 1000000000 cells/l

Isidora Milosavljevic

Assistant professor

University of Kragujevac

Pharmanova d.o.o., Obrenovac, Serbia

Groupe 1: (cases) 45 women who were found to have surgically and histolopathologically -confirmed endometriosis. Endometrial samples(1-2 gram) will be taken by laparoscopy which is the gold standard for definitive diagnosis of endometriosis.
Group2:(control) 45women who were free of endometriosis. Endometrial samples(1-2 gram) will be taken by punch biopsy.

Endometrial samples(1-2 gram) will be separated from each women during proliferative phase(days 5-15) and washed several times with 0.9% sterile saline solution to remove any blood from the tissues. The tissue samples will homogenized by tissue homogenizer at 40,000rpm. The supernatant extracts will be collected in Ependorf tubes and frozen at -80°C till analysis by ELISA

Endometriosis

Endometrial samples(1-2 gram) will be separated from each women during proliferative phase(days 5-15) by laparoscopy or punch biopsy and washed several times with 0.9% sterile saline solution to remove any blood from the tissues. The tissue samples will homogenized by tissue homogenizer at 40,000rpm. The supernatant extracts will be collected in Ependorf tubes and frozen at -80°C till analysis by ELISA

samples obtained by laparoscopy or punch biopsy for analysis by ELISA

Faculty of Medicine - Assiut University

Faculty of Medicine -Assiut University

Faculty of Medicine- Assiut University

Galectin-3 in Patients With Endometriosis

galectin-3 level will be estimated in both healthy and endometriosis women by ELISA to iinvestigate the role of galectin-3 in etiology of endometriosis

Heba Magdy Mohammed

galectin-3 in women with endometriosis

Assiut University

In Test group, the free gingival graft donor sites of each experimental group received low-level laser therapy by Ezlase; Biolase® at doses of 8.6 J/cm2.

In Control Group, the low-level laser therapy by Ezlase; Biolase® was performedin a same manner with test group at free gingival graft donor sites. However, no irradiation was occurred because of not pushing the start button.

Wounds

comparision of the effects of low-level-laser therapy on wound healing of palatal donor site

Low-Level Laser Therapy by Ezlase; Biolase®

Low-level Laser Therapy in Enhancing Wound Healing and Preserving Tissue Thickness

Low-level Laser Therapy in Enhancing Wound Healing and Preserving Tissue Thickness at Free Gingival Graft Donor Sites: A Randomised Controlled Clinical Study

The 14th day H2O2 Bubbling test results that show Complete Wound Epithelization

The tissue thickness alterations (mm.) that was measured by a endodontic reamer and digital caliper was the secondary outcome

Gülbahar Ustaoğlu

Reseach Asistant

Karadeniz Technical University

research subject will be taking aspirin 1000mg (2 capsules of 500mg) every morning in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations

research subject will be taking N-acetyl-cysteine (NAC) 1000mg (2 capsules of 500mg) two times a day in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations

research subject will be taking aspirin 1000mg (2 capsules of 500mg) every morning and NAC 1000mg (2 capsules of 500mg) two times a day in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations.

research subject will be taking 4 capsules of matching sugar pill( placebo) in the morning and 2 capsules of matching placebo in the evenings in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations

research subject will be taking aspirin 1000mg (2 capsules of 500mg) every morning in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations
Aspirin: aspirin 1000mg (2 capsules of 500mg) every morning in addition to his/her antidepressant and/or mood stabilizer medicine

Aspirin

research subject will be taking N-acetyl-cysteine (NAC) 1000mg (2 capsules of 500mg) two times a day in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations
N-acetyl-cysteine (NAC): taking N-acetyl-cysteine (NAC) 1000mg (2 capsules of 500mg) two times a day in addition to his/her antidepressant and/or mood stabilizer medicine

N-acetyl-cysteine

research subject will be taking aspirin 1000mg (2 capsules of 500mg) every morning and NAC 1000mg (2 capsules of 500mg) two times a day in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations.
Aspirin and NAC: aspirin 1000mg (2 capsules of 500mg) every morning and NAC 1000mg (2 capsules of 500mg) two times a day in addition to his/her antidepressant and/or mood stabilizer medicine

Aspirin and NAC

research subject will be taking 4 capsules of matching sugar pill( placebo) in the morning and 2 capsules of matching placebo in the evenings in addition to his/her mood stabilizing drug (lithium, anticonvulsants, any atypical antipsychotics) or combinations
Sugar Pill: research subject will be taking placebo in addition to his/her antidepressant and/or mood stabilizer medicine

Sugar Pill

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

The Montgomery-Åsberg Depression Rating Scale (MADRS) is a 10 item instrument with an overall score ranging from 0 to 54 points. A higher score corresponds with more severe depressive illness.

MADRS Total Score

The Young Mania Rating Scale (YMRS) is an 11 item instrument with an overall score ranging from 0 to 60 points. A higher score corresponds with more severe manic illness.

YMRS Total Score

The MADRS is a ten-item diagnostic questionnaire used to measure the severity of depressive episodes in patients with mood disorders. A higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. The questionnaire includes questions on the following symptoms: 1. Apparent sadness; 2. Reported sadness; 3. Inner tension; 4. Reduced sleep; 5. Reduced appetite; 6. Concentration difficulties; 7. Lassitude; 8. Inability to feel; 9. Pessimistic thoughts; and 10. Suicidal thoughts.

Examine efficacy of NAC in treating depression in bipolar patients in a double-blind placebo-controlled add-on design. Proportion of patients demonstrating > 50% decrease in depression scores on the MADRS, as a Function of Treatment (on NAC treatment only). (We completed follow-up analyses with a 30% MADRS improvement criterion due to our limited sample size compared to original goals, as we fell short on patient recruitment goals and ended up with a somewhat underpowered study.)

N-Acetyl Cysteine (NAC)

Placebo

Number of Patients Demonstrating a > 50% Decrease in Depression Scores on the Montgomery-Åsberg Depression Rating Scale (MADRS)

The MADRS is a ten-item diagnostic questionnaire used to measure the severity of depressive episodes in patients with mood disorders. A higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. The questionnaire includes questions on the following symptoms: 1. Apparent sadness; 2. Reported sadness; 3. Inner tension; 4. Reduced sleep; 5. Reduced appetite; 6. Concentration difficulties; 7. Lassitude; 8. Inability to feel; 9. Pessimistic thoughts; and 10. Suicidal thoughts. This 30% MADRS reduction was analyzed in addition to initial outcome measures of 50% MADRS reduction due to the smaller than expected study sample size.

Number of Patients Demonstrating a > 30% Decrease in Depression Scores on the Montgomery-Åsberg Depression Rating Scale (MADRS)

C-reactive protein (CRP) levels are blood test markers of inflammation. Higher CRP corresponds with higher levels of inflammation. CRP is measured in milligrams per liter.

Inflammation as Indicated by C-reactive Protein (CRP) Levels

Interleukin 6 (IL-6) is an interleukin that acts as a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 is measured in picograms (pg) per milliliter (mL). Elevated interleukin-6 indicates potential immune system dysregulation and increased inflammation.

Inflammation as Indicated by Interleukin 6 (IL-6) Levels

Inflammation as Indicated by Soluble Interleukin-2 (IL-2) Receptor Levels

Inflammation as Indicated by Tumor Necrosis Factor (TNF)-Alpha Levels

Oxidative Stress as Indicated by Superoxide Dismutase Activity

Oxidative Stress as Indicated by Catalase Activity

Oxidative Stress as Indicated by Serum Thiobarbituric Acid Reactive Substances (TBARS) Levels

Baseline Allocation

Week 8 Re-Randomization

Jair C Soares, MD

Bipolar Disorder

aspirin 1000mg (2 capsules of 500mg) every morning in addition to his/her antidepressant and/or mood stabilizer medicine

taking N-acetyl-cysteine (NAC) 1000mg (2 capsules of 500mg) two times a day in addition to his/her antidepressant and/or mood stabilizer medicine

N-acetyl-cysteine (NAC)

research subject will be taking placebo in addition to his/her antidepressant and/or mood stabilizer medicine

UT Center of Excellence on Mood Disorders at Houston

UT Center of Excellence on Mood Disorders

N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder

A Double-blind Randomized Placebo-controlled Study of Aspirin and N-acetyl Cysteine as Adjunctive Treatments for Bipolar Disorder Patients (SMRI 11T-009)

catalase/asiņošana

The Effects of One Month Consumption of Standardized Aronia Melanocarpa Extract on Anemia in Patients on Hemodialysis

Galectin-3 in Patients With Endometriosis

Low-level Laser Therapy in Enhancing Wound Healing and Preserving Tissue Thickness

N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder

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