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Ultrasound Guided PECS Block for Reducing Opioid Consumption and Improving Patient Satisfaction Through Adequate Pain Control Following Breast Cancer Surgery.

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Ielogoties Reģistrēties

The traditional pain management for patients undergoing MRM has relied heavily on opioids but a number of multimodal pain control strategies also exist including combining opioids with NSAIDs, cyclooxygenase-2 inhibitors, acetaminophen and regional blocks. Recently, literature underlines the

Breast Cancer Active Surveillance, Alternative Option, Aspirin Included

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Ielogoties Reģistrēties

Breast cancer patients with diagnosis of Ductal or Lobular Invasive Carcinoma or CDis that refuse to underwent surgery or are not qualified for, and independently of age or of their actual staging, are going to be allocated, randomly and in double masked way to one of two arms: Arm 1: standard

Intraoperative Ketamine on Chronic Pain After Mastectomy

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Ielogoties Reģistrēties

Procedures Patients will be approached at the preadmission clinic or in the general ward before operation. The analgesic methods will be explained and s/he will be recruited into the study if s/he agrees. The patient will be randomized into one of three groups. The patients in the first group (C)

Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors

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Ielogoties Reģistrēties

PRIMARY OBJECTIVES: I. To determine whether treatment with docosahexaenoic acid (DHA) for 12 weeks at 1000 mg twice daily as compared to placebo reduces normal breast tissue levels of tumor necrosis factor-alpha (TNF-alpha) in overweight and obese patients with a history of stage I-III invasive

Randomized Controlled Phase II Trial of Pre-operative Celecoxib Treatment in Breast Cancer

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Ielogoties Reģistrēties

Diindolylmethane in Treating Patients With Breast Cancer

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Ielogoties Reģistrēties

PRIMARY OBJECTIVES: I. Assess change in breast density using mammogram-based breast density measures as well as a novel, quantitative fat-water ratio breast magnetic resonance imaging (FWR-MRI). II. Evaluate the effect of an escalating daily dose of DIM on serum steroid hormones (estrogen, sex

Does Postoperative Gabapentin Reduce Pain, Opioid Consumption and Anxiety and Have a Positive Effect on Health Related Quality of Life After Radical Prostatectomy?

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Ielogoties Reģistrēties

Gabapentin Gabapentin is an anti-epileptic agent originally developed to treat spasticity (1), and eventually was found to be effective against chronic neuropathic pain (1,2). Gabapentin is available as an oral preparation and is primarily absorbed in the small intestine (1). Gabapentin is not

Biomarkers in Predicting Response to Tamoxifen and Letrozole in Postmenopausal Women With Primary Breast Cancer Treated on Clinical Trial CAN-NCIC-MA17

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Ielogoties Reģistrēties

OBJECTIVES: - Assess the prognostic utility of the MGH 2-gene and the GHI 21-gene expression signatures in postmenopausal women with primary breast cancer treated with tamoxifen followed by either placebo or letrozole on clinical trial CAN-NCIC-MA17. - Assess the ability of the MGH 2-gene and the

Biomarkers in Women Receiving Chemotherapy and Celecoxib for Stage II or Stage III Breast Cancer That Can Be Removed by Surgery

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Ielogoties Reģistrēties

OBJECTIVES: - To determine the safety and efficacy of four courses of neoadjuvant chemotherapy comprising docetaxel, capecitabine, and celecoxib followed by doxorubicin hydrochloride, cyclophosphamide, and celecoxib for the treatment of women with resectable stage II or III breast cancer. - To

A Randomized Study of Sulindac in Oral Premalignant Lesions

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Ielogoties Reģistrēties

Oral precancerous lesions (OPL) represent a valuable model for clinical trials for tobacco related cancers. However, due to the relatively low prevalence of this condition in the United States, subject accrual to such trials is slow. Conversely, in India, the prevalence of oral leukoplakia is among

The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis

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Ielogoties Reģistrēties

Head and neck cancer is a major, worldwide cause of morbidity and mortality. As long as the neoplasm is confined to its organ of origin, the patient can be cured through surgical removal of the tumor mass. Unfortunately, many cancers metastasize to other sites in the body, and metastasis is the

Study on the Neoadjuvant Use of Chemotherapy and Celecoxib Therapy in Patients With Invasive Breast Cancer

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Ielogoties Reģistrēties

Letrozole and Celecoxib in Treating Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer

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Ielogoties Reģistrēties

OBJECTIVES: Primary - Determine the response rate in postmenopausal women with hormone receptor-positive locally advanced or metastatic adenocarcinoma of the breast treated with letrozole and celecoxib as first-line therapy. Secondary - Determine the time to disease progression and overall survival

Celecoxib in Treating Postmenopausal Women Who Are Undergoing Surgery for Invasive Breast Cancer

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Ielogoties Reģistrēties

PRIMARY OBJECTIVES: I. Determine whether celecoxib suppresses aromatase activity in postmenopausal women with invasive breast cancer planning to undergo surgery. SECONDARY OBJECTIVES: I. Correlate celecoxib-mediated inhibition of aromatase activity with levels of cyclooxygenase (COX)-2 and HER-2/neu

Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women

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Ielogoties Reģistrēties

OBJECTIVES: - Determine the change in proliferation in benign breast epithelial cells as measured by Ki-67/MIB-1 in premenopausal women at high risk for estrogen receptor-negative breast cancer treated with celecoxib. - Determine the feasibility of this regimen by dropout rate of these patients

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