Patient with mass effective brain tumor that undergo non-invasive intracranial pressure measurement

Tumor, Brain

Intracranial Pressure Increase

Non-invasive measurement of intracranial pressure in patients with mass effective brain Tumors

Non-invasive measurement of intracranial pressure

Kantonsspital Aarau

non_invasive_aICP_Tumor

Non-Invasive Measurement of Absolute Intracranial Pressure in Patients With Mass Effective Brain Tumors

The primary outcome is the non-invasive, absolute intracranial pressure (aICP) before brain tumor surgery, as determined by the "NON-INVASIVE ICP ABSOLUTE VALUE METER" in mmHG.

The secondary outcome is to demonstrate correlation between increased aICP and clinical and radiological signs.

Javier Fandino, MD

1 ml of 20 mg Parecoxib is given concurrently with 19 mls of 0.75% ropivacaine

19 ml of Ropivacaine at a concentration of 0.75% is given concurrently with 1 ml of 0.9% saline

Anesthesia; Functional

Anesthesia

1 ml of injectable parecoxib (Dynastat®, Pfizer) at a concentration of 20 mg/mL is given concurrently with 19 ml of 0.75% ropivacaine (Naropin®, Astra Zeneca)

Parecoxib 20 MG/ML

19 ml of 0.75% ropivacaine (Naropin®, Astra Zeneca)) is given concurrently with 1 ml of normal saline

Ropivacaine

PMC Free article link for Sterne JA et al article on multiple imputation

Hospital Universiti Sains Malaysia (HUSM)

The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

A Randomized Two-parallel Group Controlled Trial Comparing the Effects of 20mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Ultrasound-guided Supraclavicular Block for Upper Limb Surgery

Time (measured in minutes) required for a 30% decrease in sensation compared to the contralateral upper limb limb as a reference

Time (measured in minutes) from the injection of interventions until a decrease in motor power to at least grade 3

The time (measured in hours) from the injection of interventions until complete recovery in cold and pain sensation confirmed by alcohol swab and pin prick tests in all respective dermatomes of the brachial plexus (C5-T1)

Time (measured in hours) from the injection of allotted interventions until complete recovery of motor power (grade 1) in all dermatomes supplied by brachial plexus (C5-T1)

The presence of complete sensory block at 30 minutes following institution of allotted intervention

The presence of full motor block at 30 minutes following institution of allotted interventions

All individual participant data (IPD) will be shared with other researchers. These include all primary and secondary outcomes of interest and covariate information which include the clinical and demographic profiles of patients.

Wan Nor Arifin Wan Mansor

Universiti Sains Malaysia

1 capsule of 200mg Celebrex twice a day for 14 days

1 tablet of 385mg Ibuprofen twice a day for 14 days

1 tablet of 50mg Tramadol twice a day for 14 days

Rotator Cuff Tear

1 capsule of 200mg Celebrex PO(per oral) twice a day for 14 days

Celecoxib

1 tablet of 385mg Ibuprofen PO(per oral) twice a day for 14 days

Ibuprofen

1 tablet of 50mg Tramadol PO(per oral) twice a day for 14 days

Tramadol

A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair

A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair: A Prospective Randomized Comparison

Assessed by a musculoskeletal radiologist using MRI and ultrasonography

Decrease in the VAS (pain in mm) from Day 0 to Day 730

Increase in the VAS (satisfaction in mm) from Day 0 to Day 14

frequency of adverse effects at Day 3 and Day 14

Joo Han Oh

Professor

Seoul National University Bundang Hospital

500 milliliters of intravenous ringers lactate administered over 30 minutes prior to ECT for treatments 1,2 and 3

300mg/8milliliters of intravenous ibuprofen/caldolor over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments # 1, 2 and 3

500 mL of ringers lactate over 30 minutes to be administered prior to ECT for treatments 1,2 and 3
Placebo infusion: Identically appearing placebo dose administered IV prior to ECT and subsequently on ECT treatments 2 and 3

Sugar Water

800mg/8mL of intravenous ibuprofen over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments # 1, 2 and 3
ibuprofen intravenous: IV ibuprofen 800mg/8ml given over 30 minutes prior to ECT and subsequently on ECT treatments 2 and 3

Total

Sex: Female, Male

Region of Enrollment

examination of participants to confirm cognitive ability. Questions such as who is the president, what is the day of the week, the date. The scale is from 0-30. Value of 24 or higher indicates absence of cognitive impairment

Mini Mental State Examination >23

subject self reporting rating scale for severity of myalgias utilizing numeric rating scale 0= no pain, 1-3= mild pain, annoyance with little interference with Activities of Daily Living (ADL), 4-6= moderate (interferes significantly with ADL, 7-10 = severe pain unable to perform ADL

500 mL of ringers lactate over 30 minutes to be administered prior to ECT for treatment 1, at one hour following procedure

Sugar Water-one Hour After Treatment #1

800mg/8mL of intravenous ibuprofen over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments # 1, 2 and 3
subject report of myalgia one hour after completion of procedure number 1

Ibuprofen One Hour After Treatment #1

Subject reported myalgia 6 hours after completion of treatment # 1,

Sugar Water 6 Hours After Procedure #1

subject reported myalgia 6 hours after treatment 1

Ibuprofen 6 Hours After Treatment #1

subject reported myalgia 24 hours after completion of procedure 1

Sugar Water 24 Hours After Treatment #1

subject reported myalgia 24 hours after procedure 1

Ibuprofen 24 Hours After Treatment 1

subject reported myalgia 48 hours after procedure 1

Sugar Water 48 Hours After Procedure 1

subject reported myalgia 48 hours after treatment day 1

Ibuprofen 48 Hours After Treatment 1

Subject Self Reported Numerical Rating of Incidence and Severity of Post-Electroconvulsive Therapy Myalgias After Treatment 1

Subject self reported numerical rating of incidence and severity of post ECT Myalgia after treatment day 2 0=no pain, 1-3=mild pain (annoying, little interference with ADL), 4-6= moderate,( interferes significantly with ADL) 7-10 severe pain (unable to perform everyday activities)

500 mL of ringers lactate over 30 minutes to be administered prior to ECT for treatments 2
Placebo infusion: Identically appearing placebo dose administered IV prior to ECT and subsequently on ECT treatment day 2

Sugar Water-one Hour After Treatment 2

800mg/8mL of intravenous ibuprofen over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments # 2 one hour after treatment
ibuprofen intravenous: IV ibuprofen 800mg/8ml given over 30 minutes prior to ECT treatment day 2

Ibuprofen One Hour After Treatment #2

Subject reported myalgia 6 hours after completion of treatment #2

Sugar Water 6 Hours After Procedure #2

Ibuprofen 6 Hours After Treatment #2

Subject reported myalgia 24 hours after completion of treatment #2

Sugar Water 24 Hours After Treatment #2

Ibuprofen 24 Hours After Treatment #2

Subject reported myalgia 48 hours after completion of treatment #2

Sugar Water 48 Hours After Treatment 2

Ibuprofen 48 Hours After Treatment 2

Myalgia Reported on Treatment Day 2

Subject self reported severity of myalgia based on a self reported assessment utilizing numeric rating scale 0=no myalgia, 1-3=mild myalgia (annoying, little interference with ADL);4-6=moderate (interferes significantly with ADL); 7-10 severe myalgia(unable to perform every day activities)

500 mL of ringers lactate over 30 minutes to be administered prior to ECT for treatments 3
Placebo infusion: Identically appearing placebo dose administered IV prior to ECT and subsequently on ECT treatment day 2

Sugar Water-one Hour After Treatment 3

800mg/8mL of intravenous ibuprofen over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments # 3 one hour after treatment
ibuprofen intravenous: IV ibuprofen 800mg/8ml given over 30 minutes prior to ECT treatment day 2

Ibuprofen One Hour After Treatment #3

Subject reported myalgia 6 hours after completion of treatment #3

Sugar Water 6 Hours After Procedure #3

Ibuprofen 6 Hours After Treatment #3

Subject reported myalgia 24 hours after completion of treatment #3

Sugar Water 24 Hours After Treatment #3

Ibuprofen 24 Hours After Treatment #3

Subject reported myalgia 48 hours after completion of treatment #3

Sugar Water 48 Hours After Treatment 3

Ibuprofen 48 Hours After Treatment 3

Myalgia Reported After Treatment #3

Subject self reported numerical rating of incidence and severity of Post ECT pain score for headache at 1, 6, 24 and 48 hours post procedure. Pain Rating 0= no pain, 2-4=moderate pain, 5-7=distressing severe pain, 8-9=intense very severe pain, 10=unbearable pain

500 mL of ringers lactate over 30 minutes to be administered prior to ECT for treatments 1
Placebo infusion: Identically appearing placebo dose administered IV prior to ECT and subsequently on ECT treatment day 1

Pain Score Sugar Water-one Hour After Treatment 1

800mg/8mL of intravenous ibuprofen over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments # 1 one hour after treatment
ibuprofen intravenous: IV ibuprofen 800mg/8ml given over 30 minutes prior to ECT treatment day 2

Pain Score Ibuprofen One Hour After Treatment #1

Subject reported headache 6 hours after completion of treatment #1

Pain Score After Sugar Water 6 Hours After Treatment #1

Pain Score Ibuprofen 6 Hours After Treatment #1

Subject reported headache 24 hours after completion of treatment #1

Pain Score Sugar Water 24 Hours After Treatment #1

Subjects reported headache 24 hours after completion of treatment #1

Pain Score Ibuprofen 24 Hours After Treatment #1

Subjects reported headache 48 hours after completion of treatment #1

Pain Score Sugar Water 48 Hours After Treatment 1

Pain Score Ibuprofen 48 Hours After Treatment 1

Subject Self Reported Numerical Rating of Incidence and Severity of Post Electroconvulsive Therapy Headache After Treatment Day 1

Subject self reported numerical rating of incidence and severity of post ECT headache 0=no pain, 2-4=moderate pain, 5-7= distressing severe pain, 8-9= very severe pain, 10=unbearable pain.

800mg/8mL of intravenous ibuprofen over 30 min in 500mL of ringers lactate to be administered prior to ECT for treatments #2 one hour after treatment
ibuprofen intravenous: IV ibuprofen 800mg/8ml given over 30 minutes prior to ECT treatment day 2

Subject reported headache 6 hours after completion of treatment #2

Subject reported headache 24 hours after completion of treatment #2

Subject reported headache 48 hours after completion of treatment #2

Sugar Water 48 Hours After Treatment #2

Ibuprofen 48 Hours After Treatment #2

Incidence and Severity of Headache After ECT Treatment 2

Subject self reported numerical rating of incidence and severity of post ECT headache after treatment #3, 0=no pain, 2-4=moderate pain, 5-7=distressing severe pain, 8-9 very serious pain, 10=unbearable pain.

Subject reported headache 6 hours after completion of treatment #3

Subject reported headache 24 hours after completion of treatment #3

Subject reported headache 48 hours after completion of treatment #3

Incidence of Headache & Severity Headache After ECT Treatment #3

Overall Study

Vasanti Tilak, MD

Depression, Myalgia

Identically appearing placebo dose administered IV prior to ECT and subsequently on ECT treatments 2 and 3

Placebo infusion

IV ibuprofen 800mg/8ml given over 30 minutes prior to ECT and subsequently on ECT treatments 2 and 3

cyclooxygenase/seizures

non_invasive_aICP_Tumor

The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair

IV Ibuprofen for Post-Electroconvulsive Therapy Myalgia

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