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elastase/iekaisums

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PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort

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Ielogoties Reģistrēties
INTRODUCTION 1.1 BACKGROUND Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is a new rapidly spreading infectious disease with no proven treatment options. The virus causes a spectrum of disease ranging from mild coryzal symptoms to severe respiratory compromise requiring
This is a Phase 2, , randomized (1:1:1), placebo-controlled, 2-weeks, proof-of-concept study to evaluate the safety and tolerability as well as the mechanistic effect of oral administration of potent inhibitor of neutrophil elastase(Inhaled All trans retinoic acid and inhaled isotretinoin in

Nebulised Dornase Alfa for Treatment of COVID-19

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Ielogoties Reģistrēties
Dornase alfa is a recombinant human DNase enzyme indicated in conjunction with standard therapies for the management of cystic fibrosis (CF) to improve pulmonary function. Dornase alfa degrades extracellular DNA, and so promotes the clearance of NETs and lead to a significant improvement in lung

Effect of Thrombin-containing Collagen-based Hemostatic Matrix

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Ielogoties Reģistrēties
1. Synopsis - Title: Randomized controlled Study to evaluate the Effect of Thrombin-containing Collagen-based Hemostatic Matrix on Prevention of Pancreatic fistula after Pancreatectomy - Study center: Single center from Korea - Study type: Single center prospective randomized controlled study -

Roflumilast in Non-CF Bronchiectasis Study (2019)

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Ielogoties Reģistrēties
In a 4-week crossover study in 38 patients with COPD, roflumilast 500μg daily significantly reduced sputum absolute neutrophil count, IL-8 and neutrophil elastase compared with placebo treatment. Interestingly, the mechanism of anti-neutrophilic inflammation with roflumilast treatment in patients

Impact of Pumps on Internal Thoracic Arteries (IPITA)

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Ielogoties Reģistrēties
Eighty elective male patients undergoing CABG were selected using one or two internal thoracic arteries under CPB with a roller pump (RP group) or centrifugal pump (CFP group). ITA samples were collected before starting CPB (Time 1) and before the last coronary anastomosis during aortic cross

A Pilot Study to Evaluate the Use of the Vest® System for Treatment of Bronchiectasis Patients in the Home Setting

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Ielogoties Reģistrēties
Patients with NCFBE who require regular home airway clearance therapy will be eligible to be screened for inclusion in the study. After enrollment, baseline data including demographics, pulmonary related medical history including acute exacerbations (pulmonary-related hospitalizations, ED visits and

Clinical Study Assessing the Effect of ZIVEREL® in Cancer Patients

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Ielogoties Reģistrēties
Hyaluronic acid is a glycosaminoglycan formed by glucuronic acid and N acetylglucosamine disaccharide units. It is found mainly in the extracellular matrix of the loose connective tissue and is associated with several key processes, including cell signaling and repair, as well as with tissue

Effect of Roflumilast on Quality of Life, Lung Function and Mucus Properties in Patients With Bronchiectasis

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Ielogoties Reģistrēties

The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity

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Ielogoties Reģistrēties
The experiments proposed here seek to identify mechanisms underlying changes in the human uterine myometrial artery reactivity during pregnancy. The first series of experiments will be to address the changes that have been observed in stress-strain relationships and arterial remodeling during

Woodsmoke Particulate + Prednisone

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Ielogoties Reģistrēties
Military deployment is associated with exposure to novel particulate matter (PM), such as from burn pits, aeroallergens, and increased cigarette consumption. War fighters exposed to these inhalational exposures exhibit immediate and chronic respiratory morbidity. For example, military service

Gastrointestinal Study at Orkambi Therapy in CF Patients

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Ielogoties Reģistrēties
To examine the entire intestinal mucosa via capsule endoscopy before and 6 months after Orkambi therapy to ascertain if the inflammatory changes in the intestine have improved. A marker of intestinal inflammation measured in the stool, Calprotectin, will be examined before and 6 months after Orkambi

Woodsmoke Particulate + Hypertonic Saline

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Ielogoties Reģistrēties
Military deployment is associated with exposure to novel particulate matter (PM), such as from burn pits, aeroallergens, and increased cigarette consumption. War fighters exposed to these inhalational exposures exhibit immediate and chronic respiratory morbidity. For example, military service

Airway Remodeling During Mepolizumab Treatment

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Ielogoties Reģistrēties
1. Scientific Rationale & Hypothesis: Chronic airway changes, such as smooth muscle hypertrophy/hyperplasia, reticular basement membrane thickening, goblet cells hyperplasia characterize severe asthma. Chronic inflammation, and especially eosinophilia and T2 cytokines are involved in these
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