fagopyrum zuogongense/leikēmija

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Suppressive activity of protease inhibitors from buckwheat seeds against human T-acute lymphoblastic leukemia cell lines.

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Ielogoties Reģistrēties

The buckwheat protease inhibitor designated BWI-1, a member of the potato inhibitor I family, inhibits trypsin, chymotrypsin, and subtilisin, whereas the buckwheat protease inhibitor designated BWI-2a, a novel protease inhibitor homologous to the vicilin family, inhibits only trypsin. We examined

Buckwheat polysaccharide exerts antiproliferative effects in THP-1 human leukemia cells by inducing differentiation.

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Ielogoties Reģistrēties

Buckwheat is a healthy food commonly eaten worldwide. The antitumor activity of buckwheat polysaccharides (BWPSs) has not yet been evaluated. In recent years, inducing differentiation of leukemic cells has become one of the most important therapeutic approaches for curing leukemia, and this strategy

Induction of apoptosis by buckwheat trypsin inhibitor in chronic myeloid leukemia K562 cells.

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Ielogoties Reģistrēties

Buckwheat is an ancient and specialty grain in China. Due to its unique chemical and bio-activity components, buckwheat has been found to have many uses in food products and medicine. However, very little is known about the toxicity of protease inhibitors from buckwheat. Here, the possible effects

Stimulation of dendritic cell maturation and induction of apoptosis in lymphoma cells by a stable lectin from buckwheat seeds.

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Ielogoties Reģistrēties

The present study aims to purify and characterize lectin from tartary buckwheat seeds and study its properties as well as biological activities to determine its possible biomedical applications in promoting maturation and proliferation of peripheral blood DCs derived from healthy donors and to study

Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract.

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Ielogoties Reģistrēties

The anti-allergic action of buckwheat grain extract (BGE) was investigated using rodent experimental models. The oral, intraperitoneal and intradermal administration of BGE significantly inhibited the compound 48/80-induced vascular permeability documented by Evans blue extravasation. In addition,

[Apoptosis of HL-60 cells induced by recombinant common Buckwheat trypsin inhibitor].

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Ielogoties Reģistrēties

The study was purposed to investigate the apoptosis of HL-60 cells induced by recombinant common buckwheat trypsin inhibitor (rBTI) and its mechanism. The inhibition rate of rBTI on HL-60 cells was detected by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide); the morphology of

Tartary buckwheat flavonoid activates caspase 3 and induces HL-60 cell apoptosis.

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Ielogoties Reģistrēties

It has been proposed that flavonoids may have potential as anticancer agents. In this study, we showed that tartary buckwheat flavonoid (TBF) obviously inhibits the growth of human acute myelogenous leukemia (AML) HL-60 cells by MTT assay. The inhibitory effect of TBF on the proliferation of HL-60

Conformational changes of rBTI from buckwheat upon binding to trypsin: implications for the role of the P(8)' residue in the potato inhibitor I family.

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Ielogoties Reģistrēties

BWI-1 (buckwheat trypsin inhibitor), a member of the potato inhibitor I family, suppresses the growth of T-acute lymphoblastic leukemia cells and induces apoptosis in human solid tumor cell lines. Here, we report the crystal structure of rBTI (recombinant buckwheat trypsin inhibitor), a recombinant

A relatively stable antifungal peptide from buckwheat seeds with antiproliferative activity toward cancer cells.

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Ielogoties Reģistrēties

An antifungal peptide with a molecular mass of approximately 4 kDa was isolated from buckwheat seeds by using ion-exchange chromatography on SP-Sepharose and Q-Sepharose, and gel filtration on Superdex peptide. The peptide was adsorbed on SP-Sepharose in 10 mM NH(4)OAc buffer (pH 4.5) and on

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