Coronary Artery Disease

IRCCS Pol. San Donato

DRUG ELUTING STENT FOR DIABETIC PATIENTS IN CORONARY ARTERY DISEASE TREATMENT

A POST MARKET REGISTRY OF ABLUMINUS® SIROLIMUS ELUTING CORONARY STENT SYSTEM FOR PERCUTANEOUS INTERVENTION IN PATIENTS WITH DIABETES MELLITUS

Luca Testa

MD; PhD

Istituto Clinico Sant'Ambrogio

IRCCS Policlinico S. Donato

walking 30 minutes per day, three days/week for 6 weeks.

Osteoarthritis, Knee

Pain

Physical Activity

Mitochondrial Pathology

walking 30 minutes per day, three days/week for 6 weeks with a member of study team.

Walking

University of Maryland, Baltimore

Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

Bioenergetics, Inflammation, and Protein Expression as Mechanisms for Variation in Pain Sensitivity After Physical Activity in Adults With Knee Osteoarthritis

Change from baseline pain threshold/tolerance after 30 minutes of walking

Change from baseline pain threshold/tolerance after six weeks of walking for 30 minutes three days/week

platelet oxygen consumption as indicator of cellular energy production via oxidative phosphorylation or glycolysis; mitochondrial copy number; mitochondrial proteins

c-reactive protein (CRP), Interleukin (IL)-1, IL-1β, IL-6, IL-10, Tumor Necrosis factor-alpha (TNF-α), prostaglandin-e (PGES)

Platelet protein signatures will be explored using nanocapillary liquid chromatography-mass spectrometry (LC-MS/MS) coupled to an Orbitrap MS that combines two mass analyzers to allow simultaneous precursor ion scans from which relative quantitative data is derived between two groups (hi and low pain groups) and fragmentation data from which peptide sequence matches are made.

This is a pilot study with a very small sample size.

Jennifer Klinedinst

Associate Professor

National Institute of Nursing Research (NINR)

Adults with knee osteoarthritis and healthy controls will both undergo the same walking intervention. The goal is to examine basic mechanism for pain sensitivity after walking.

Modified Jessner's solution will be applied on the right side and glycolic acid 70% on the other side of the face.trichloroacetic acid 20% will be applied in one uniform coat to both sides

Melasma

Modified Jessner's solution will be applied on the right side until frosting

Modified Jessner's solution

Glycolic acid 70% on the other side of the face, then it will be neutralized with water after 5 minutes

Glycolic acid

Trichloroacetic acid 20% will be applied in one uniform coat to both sides of the face until frosting

Trichloroacetic acid

Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid

The Efficacy of Combined Peels in Treatment of Melasma Using Modified Jessner's Solution With 20%Trichloroacetic Acid Versus 70%Glycolic Acid With 20% Trichloroacetic Acid : A Split-face Study

MASI = .3A(D+H) [forhead] + .3A(D+H)[right malar] + .3A(D+H)[left malar] + .1A(D+H)[chin]; A = area, D = darkness, and H = homogeneity. Area is based on percentage of the region covered by melasma using a 1-6 scale. Darkness is determined on a 0-3 scale. Homogeneity is based on a 0-4 scale.

Photos were evaluated using the grading of worse, no improvement, mild improvement or marked improvement comparing week 12 to baseline.

lactic acid/necrosis

DRUG ELUTING STENT FOR DIABETIC PATIENTS IN CORONARY ARTERY DISEASE TREATMENT

Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid

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