leptospirosis/carbohydrate

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A case of leptospirosis simulating colon cancer with liver metastases.

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Ielogoties Reģistrēties

We report a case of a 61-year-old man who presented with fatigue, abdominal pain and hepatomegaly. Computed tomography (CT) of the abdomen showed hepatomegaly and multiple hepatic lesions highly suggestive of metastatic diseases. Due to the endoscopic finding of colon ulcer, colon cancer with liver

Antigens recognized by the human immune response to severe leptospirosis in Barbados.

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Ielogoties Reģistrēties

Serum samples obtained from patients hospitalized in Barbados with severe leptospirosis were tested by the microscopic agglutination test (MAT), enzyme immunoassay (EIA) and immunoblotting with leptospires that had been isolated from these patients. While serum samples taken a few days after onset

A monoclonal antibody reacting with a determinant on leptospiral lipopolysaccharide protects guinea pigs against leptospirosis.

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Ielogoties Reģistrēties

An IgA monoclonal antibody (MUM/F1-1/copenhageni) was produced from a mouse immunised with Leptospira interrogans serovar copenhageni. The antibody showed partial serogroup specificity by agglutination and by reaction in enzyme immunoassay, and opsonised homologous leptospires for phagocytosis by

Recombinant LipL32 and LigA from Leptospira are unable to stimulate protective immunity against leptospirosis in the hamster model.

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Ielogoties Reģistrēties

The major antigenic component of pathogenic Leptospira spp. is lipopolysaccharide (LPS). However, due to the specificity of the immune response generated towards LPS and the diversity in leptospiral LPS carbohydrate structure, current commercial vaccines stimulate protection only against homologous

Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane.

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Ielogoties Reģistrēties

BACKGROUND Leptospira interrogans is the major causative agent of leptospirosis. Phagocytosis plays important roles in the innate immune responses to L. interrogans infection, and L. interrogans can evade the killing of phagocytes. However, little is known about the adaptation of L. interrogans

Genetic diversity among major endemic strains of Leptospira interrogans in China.

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Ielogoties Reģistrēties

BACKGROUND Leptospirosis is a world-widely distributed zoonosis. Humans become infected via exposure to pathogenic Leptospira spp. from contaminated water or soil. The availability of genomic sequences of Leptospira interrogans serovar Lai and serovar Copenhageni opened up opportunities to identify

Isolation and characterization of partially purified leptospiral antigens.

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Ielogoties Reģistrēties

The methanol extract of Leptospira interrogans serovar canicola was purified by precipitation with acetone or acetone and chloroform. The antigenicity of the antigen was not altered by heating or treatment with pepsin and pronase. However the antigenicity was lost when the antigen was treated with

Characterization of trypsin extractable antigens of Leptospira interrogans serovars pomona, bataviae & L. biflexa serovar patoc.

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Ielogoties Reģistrēties

Leptospira strains after treatment with trypsin released an antigen (Tx) which consisted of protein (4.2 mg/ml), carbohydrate (0.39 mg/ml) and hexosamine (0.025 mg/ml). Immunodiffusion, immunoelectrophoresis and indirect haemagglutination tests revealed serological cross reactions among the three

Comparative analysis of lipopolysaccharides of pathogenic and intermediately pathogenic Leptospira species.

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Ielogoties Reģistrēties

BACKGROUND Lipopolysaccharides (LPS) are complex, amphipathic biomolecules that constitute the major surface component of Gram-negative bacteria. Leptospira, unlike other human-pathogenic spirochetes, produce LPS, which is fundamental to the taxonomy of the genus, involved in host-adaption and also

Leptospira interrogans is recognized through DC-SIGN and induces maturation and cytokine production by human dendritic cells.

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Ielogoties Reģistrēties

Leptospirosis is a global zoonotic disease, caused by pathogenic Leptospira species including Leptospira interrogans, that causes public health and livestock problems. Pathogenesis, immune response and cellular receptors for Leptospira are not well understood. Interaction of dendritic cells (DCs)

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