linolenic acid/sarcoma

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Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells.

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Ielogoties Reģistrēties

In this study it is shown that gamma-linolenic acid (GLA) at concentrations of 10, 20 and 50 micrograms/ml has a dose-responsive inhibitory effect on mitosis in osteogenic sarcoma cells after exposure for 24, 48 and 72 hours, respectively. GLA also has marked effects on the morphology of the nucleus

Some effects of the essential fatty acids linoleic acid and alpha-linolenic acid and of their metabolites gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and of prostaglandins A1 and E1 on the proliferation of human osteogenic sarcoma cells in culture.

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Ielogoties Reģistrēties

Gamma-linolenic acid has been shown to suppress the rate of proliferation of a number of malignant cell lines in culture. To test the proposal that this was a specific prostaglandin 1- or 2-series effect, 379 batches of MG63 human osteogenic sarcoma cells were seeded in Greiner flasks and cultured

The effect of gamma-linolenic acid on the growth of human osteogenic sarcoma and oesophageal carcinoma cells in culture.

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Ielogoties Reģistrēties

A statistically highly significant growth-suppressive effect of the prostaglandin precursor gamma-linolenic acid (GLA) on MG63 human osteogenic sarcoma and oesophageal carcinoma cells in culture was found. In view of the results reported on the growth-suppressive effect of GLA on cancer cells in

Effects of gamma-linolenic acid on murine cells in vitro and in vivo.

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Ielogoties Reģistrēties

The effects of gamma-linolenic acid (GLA) on growth of cells of the continuous murine sarcoma line M52B were investigated in vitro. Prostaglandin (PG) production by these cells after GLA treatment was also measured. GLA inhibited the growth of M52B cells and became overtly toxic at high doses or

Essential fatty acids and acquired immunodeficiency syndrome.

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Ielogoties Reģistrēties

Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) that is characterized by profound immunodeficiency, opportunistic infections and Kaposi's sarcoma. As yet no effective therapy is available for AIDS, though retroviral drugs are able to prolong life and contain

[Nature of the modifying action of polyunsaturated fatty acids on the growth of transplantable tumors of different types].

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Ielogoties Reģistrēties

Modification effect of sodium salts and ethers of linolenic, arachidonic and alpha-linolenic acids on the growth of transplantable mouse tumors was examined. Polyunsaturated fatty acids (PUFA) enhanced the growth of mammary adenocarcinoma Ca-755, whereas the opposite effect was observed in mice with

Arachidonic acid stimulates cell growth in an osteoblastic cell line, MC3T3-E1, by noneicosanoid mechanism.

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Ielogoties Reģistrēties

Arachidonic acid, added to alpha-minimum essential medium containing 10% fetal bovine serum at the final concentration of 10(-4) M, significantly increased DNA content of an osteoblastic cell line, MC3T3-E1, along with an increase of DNA synthesis. No growth-stimulatory effect of arachidonic acid

Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo.

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Ielogoties Reģistrēties

Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there

Effects of fatty acid modification of ascites tumor cells on pulmonary metastasis in rat.

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Ielogoties Reģistrēties

Yoshida sarcoma cells were incubated with each of 4 different saturated and 17 different unsaturated fatty acid methyl and ethyl esters in order to modify the fatty acid composition of the cell membrane, and a possible correlation between the lipid fluidity of the cell membrane and the metastatic

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