16 patients confirmed with a diagnosis of invasive ductal carcinoma who will undergo wide local excision surgery or mastectomy. All patients in the single arm will undergo a 5 day intervention drinking concentrated beetroot juice and 2 magnetic resonance imaging scan sessions pre and post intervention. MRI scan sessions will be composed of research scans including diffusion and lipid profiling MR imaging methods and MR spectroscopy (MRS) methods.

Malignant Breast Tissue Neoplasm

The patient will follow a 5 day dietary nitrate intervention programme, taking 3 doses of 7cl (0.4 g nitrate per dose) concentrated beetroot juice (SPORT shot, James White Drinks, Suffolk, U.K.) a day.

Beetroot juice

Aberdeen Biomedical Imaging Centre

Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?

Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis (AG) in Breast Cancer? - A Longitudinal Study Using Specialist Magnetic Resonance (MR) Methods

Lipid peak volume ratio with units of ratio

Water displacement with units of micrometer

University of Aberdeen

NHS Grampian

Over the 7 days preceding each testing session, participants will consume 140 ml per day of beetroot juice (Beet It (HeartBeet Ltd.), Ipswich, UK). During this time participants will be asked to abstain from use of antiseptic mouthwash as this has been shown to temporarily kill the bacteria that facilitate the reduction of nitrate to nitrite. All participants will be asked to refrain from consuming any antioxidant (e.g., Vit E or Fish Oil) supplements during the course of the study as these may impact the study findings.

Over the 7 days preceding each testing session, participants will consume 140 ml per day of a nitrate-depleted placebo. During this time participants will be asked to abstain from use of antiseptic mouthwash as this has been shown to temporarily kill the bacteria that facilitate the reduction of nitrate to nitrite. All participants will be asked to refrain from consuming any antioxidant (e.g., Vit E or Fish Oil) supplements during the course of the study as these may impact the study findings.

Cancer Survivor With History of Anthracycline Chemotherapy

Following randomization on day 1, subjects will consume either the nitrate or nitrate-free beverage for 7 days with outcome measurements performed on day 7. Following a 7 day washout, subjects will then consume the crossover beverage for 7 days with outcome measures performed on day 21.

Black currant juice

Kansas State University - Clinical Integrative Physiology Laboratory

Cardiovascular Function in Cancer Survivors

Therapeutic Role of Dietary Nitrates on Cardiovascular Function in Cancer Survivors Treated With Anthracycline Chemotherapy

Left ventricular function as measured by transthoracic echocardiography

Vascular function measured as changes in arterial stiffness and endothelial function.

Local limb blood pressure measured in millimeters of mercury (mmHg) following study interventions/arms

Carl Ade, M.S., Ph.D.

Assistant Professor

Kansas State University

This study utilizes a 7-day randomized, double-blind, placebo-controlled crossover study design, in which individuals are initially supplemented with a nitrate-rich supplement in the form of a specifically formulated beetroot juice, or nitrate-poor placebo. Individuals will then entered a 7-day washout period before entering the opposing arm of the study.

The supplement and placebo will be distributed to the individual by a member of the research team who is not involved with data collection or analysis.

nitrate/krūts vēzis

Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?

Cardiovascular Function in Cancer Survivors

The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis

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