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PTP1B Implication in the Vascular Dysfunction Associated With Obstructive Sleep Apnea

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The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

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Ielogoties Reģistrēties
In a prospective, randomized clinical trial of de novo mandibular fracture patients requiring intraoral surgical repair with plating, the investigators will: 1. Compare the effects of supplemental vitamin C to placebo on soft tissue wound healing, measured by a) biomarkers of soft tissue repair

Role of Geminin and Mcm-2 in Prognosis of Renal Cell Carcinoma

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Ielogoties Reģistrēties
Renal cell carcinoma (RCC) is one of the most common urological malignancies. Approximately 338,000 people are diagnosed with RCC worldwide each year, representing approximately 2-3 % of all cancers. RCC can be classified into non-epithelial and epithelial, according to cell origin. The four major

Molecular Mechanisms of microRNA-494 Involving in Cerebral Ischemia

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Ielogoties Reģistrēties
Surgery and anesthesia are stressful events, thus there is a possibility that liver enzymes and bilirubin may increase postoperatively. Mild elevations of serum aminotransferase, alkaline phosphatase, or bilirubin levels are frequent after surgical procedures, whether performed under general or

Ramipril Treatment of Claudication

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Ielogoties Reģistrēties
This is an interventional study of PAD patients that exhibit claudication. The purpose of this study is to determine the potential mechanisms by which Ramipril vastly improves the walking performance of these patients. The study will be achieved through these specific aims: Specific Aim #1: Test the

Planetary Habitat Simulation: Bone Metabolism Studies

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Ielogoties Reģistrēties
The risk of bone loss in response to immobilization and space flight is widely recognized, with such bone losses occurring predominantly in the legs. Loading forces in the lower extremities are typically low in space and during bed rest, but musculoskeletal loading countermeasures can prevent or

Palliative Thoracic Radiotherapy Plus BKM120

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Ielogoties Reģistrēties
This study will be a single-centre, open-label, 3+3 cohort, dose escalation phase I study of the use of buparlisib in combination with thoracic radiotherapy. Patients with incurable NSCLC requiring palliative thoracic radiotherapy will be eligible for entry. The first three cohorts of patients will

Chinese Herbal Formulation PHY906 and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer

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Ielogoties Reģistrēties
PRIMARY OBJECTIVES: I. To characterize the safety and tolerability of KD018 (Chinese herbal formulation PHY906) in combination with daily sorafenib (sorafenib tosylate) and to determine the maximum tolerated dose (MTD) of the combination of KD018 plus sorafenib to bring forward into phase

Role of Nox2 in CNI-induced Renal Fibrosis

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Ielogoties Reģistrēties
Calcineurin Inhibitors (CNIs) and Renal Fibrosis. CNIs including CsA and tacrolimus are the cornerstone of maintenance immunosuppression in solid organ transplantation. These drugs are so effective that newer generation CNIs such as Voclosporin (Isotechnika Pharma, Inc, Edmonton, Alberta) are in

Normobaric Hyperoxygenation for Prevention of Contrast Induced Nephropathy

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Ielogoties Reģistrēties
Acute renal failure induced by radiographic contrast agents is a known complication of coronary angiography. It has been demonstrated that following contrast media application the renal outer medullar blood flow is reduced, resulting in medullar ischemia. N-acetylcysteine (NAC) together with well

Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma

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Ielogoties Reģistrēties
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide with an incidence of over 600,000 new cases and almost as many deaths annually.1 Advanced stages of disease at diagnosis often preclude curative treatments, and the overall prognosis of patients diagnosed with advanced HCC

A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema

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Ielogoties Reģistrēties
Diabetic retinopathy is a major cause of visual impairment in the United States. Diabetic macular edema (DME) is a manifestation of diabetic retinopathy that produces loss of central vision. Data from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) estimate that after 15 years of
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