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phospholipase/vēzis
Saite tiek saglabāta starpliktuvē
Lappuse 1 no 24 rezultātiem
Reduction of mammalian neoplasms with phospholipase A2 activating substances
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
BACKGROUND OF THE INVENTION
Mammalian response to injury or inflammation is a complex series of events. Shortly after an event which elicits an inflammatory cascade, the release of eicosanoids is initiated. The release of eicosanoids is mediated by the activation of Phospholipase A.sub.2 (PLA.sub.2)
Inhibitors of phosphoinositide-specific phospholipase C
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
BACKGROUND OF THE INVENTION
Phospholipases C (EC 3.1.4.3) are a family of enzymes which hydrolyze the sn-3 phosphodiester bond in membrane phospholipids producing diacylglycerol and a phosphorylated polar head group. Mammalian phospholipase C (PLC) enzymes exhibit specificity for the polar head
Methods for preventing multidrug resistance in cancer cells
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is directed to methods for preventing the emergence of multidrug resistance in tumor cells during cancer chemotherapy. In particular, it relates to the use of inhibitors of particular pathways of signal transduction to prevent the
Methods and compositions for treatment of arthritis and cancer
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
FIELD OF THE INVENTION
The present invention pertains to a novel 18-residue dimerized peptide designated PIP [59-67] dimer, having dual inhibitory activity against secretory phospholipase A2 (sPLA2) and matrix metalloproteinases (MMPs). This novel peptide inhibitor of the invention not only inhibits
Non-steroidal anti-inflammatory agent therapy for epithelial cell cancer
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
The present invention relates to methods and compositions that provide for the diagnosis and treatment of prostatic intraepithelial neoplasia. A particular aspect of the invention relates to methods and compositions containing compounds which inhibit phospholipase A.sub.2, particularly those that
Phospholipase A2 inhibitors as mediators of gene expression
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the fields of radiation biology and cell biology. More particularly, it concerns the attenuation of the effect of ionizing radiation induced activation of tumor necrosis factor by inhibitors of
Phospholipase A2 inhibitors as mediators of gene expression
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the fields of radiation biology and cell biology. More particularly, it concerns the attenuation of the effect of ionizing radiation induced activation of tumor necrosis factor by inhibitors of
Phospholipase D polypeptide and DNA sequences
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
TECHNICAL FIELD
This invention is in the field of molecular biology and particularly relates to nucleic acid sequences that encode novel phospholipases.
BACKGROUND
The mechanism by which specificity of physiological responses are conferred by a limited number of signal transducing substances,
Phospholipase D polypeptide and DNA sequences
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
TECHNICAL FIELD
This invention is in the field of molecular biology and particularly relates to nucleic acid sequences that encode novel phospholipases.
BACKGROUND
The mechanism by which specificity of physiological responses are conferred by a limited number of signal transducing substances,
Method of screening substance useful in treating disease with the use of GPR40 and phospholipase
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a national phase entry under 35 U.S.C. .sctn.371 of International Application No. PCT/JP2006/320611, filed Oct. 17, 2006, published in Japanese, which claims benefit of Japanese Patent Application No. 2005-321108, filed Nov. 4, 2005.
Treatment of tumors
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
FIELD OF THE INVENTION
This invention relates to treatment of mammals, including humans suffering from cancerous tumors, particularly malignant gliomas and other tumors of the central nervous system, and to tumor models for evaluating effectiveness of such treatments.
BACKGROUND OF THE INVENTION
In
Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
The present invention relates to methods and compositions that prevent or inhibit metastases of cancers of epithelial cell origin, especially human prostate cancers. A particular aspect of the invention relates to methods and compositions that inhibit arachidonic acid release in cells of these
Kit for indentifying prostatic intraepithelial neoplasia (PIN)
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
The present invention relates to methods and compositions that provide for the diagnosis and treatment of prostatic intraepithelial neoplasia. A particular aspect of the invention relates to methods and compositions containing compounds which inhibit phospholipase A.sub.2, particularly those that
Uteroglobin therapy for epithelial cell cancer
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
The present invention relates to methods and compositions that provide for the diagnosis and treatment of prostatic intraepithelial neoplasia. A particular aspect of the invention relates to methods and compositions containing compounds which inhibit phospholipase A.sub.2, particularly those that
Glypican-1 in human breast cancer
Rakstu tulkošanu var veikt tikai reģistrēti lietotāji
Ielogoties Reģistrēties
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present application concerns medical sciences and more particularly detection and treatment of human cancers, especially breast cancer.
2. Description of Related Art
Membrane associated heparan sulfate proteoglycans (HSPGs) are thought to
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