The present invention provides a method for preventing or treating an allergic disease, comprising administering to a subject a composition comprising an extract from Illicium verum as an active ingredient. The extract from Illicium verum of the present invention reduces the secretion amount of increased histamine by compound 48/80 and the production amount of the increased allergenic cytokines (TNF-.alpha., IL-4 and IL-8) by PMA and A23187. The Illicium verum extract of the present invention reduces edema, dermatitis and IgE concentration of serum in atopic dermatitis mouse model. The Illicium verum extract of the present invention may be efficiently use for prevention, improvement or treatment of various allergic disease such as edema, hypersensitivity, contact dermatitis, atopic dermatitis, skin allergy, asthma or urticaria as pharmaceutical compositions, skin external applications, cosmetic compositions or food compositions.

Yoon; TaeSook

Sung; Yoon-Young

Yang; Won-Kyung

Kim; Ho Kyoung

Korea Institute of Oriental Medicine

Method for preventing or treating an allergic disease using extract from illicium verum

An azaazulene derivative having the general formula (I): ##STR1## wherein R.sup.1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond or double bond; when the bond C N is single bond, R.sup.2 is 5-tetrazolyl group, R.sup.3 is taken together with carbon atom to form carbonyl group at the 2-position, and R.sup.4 is hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a lower alkenyl group, a lower alkyl group having oxygen atom or sulfur atom in carbon chain, a lower alkyl group having a halogen atom or cyano group, a lower alkyl group having heteroaromatic ring, a diphenyl lower alkyl group, or a lower alkyl group having hydrocarbon-aromatic ring with the general formula: ##STR2## in which W is single bond or carbonyl group, oxygen atom, sulfur atom or --CH.dbd.CH--, n is an integer of 1 to 6, and R.sup.1', R.sup.2' and R.sup.3' are the same or different and each is hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group, trifluoromethyl group, hydroxyl group, a lower alkoxycarbonyl group, carboxyl group, acetyl group or cyano group; when the bond C N is double bond, N at the 1-position has no substituent R.sup.4, R.sup.2 is cyano group, and R.sup.3 is amino group or a salt thereof, azido group, a diphenyl lower alkyl amino group, a substituted phenyl amino group, a substituted piperazinyl group, a substituted homopiperazinyl group, an amino acid residue bonded by N terminal group in which C terminal group is carboxyl group or a lower alkyl ester thereof, or a lower alkyl amino group which may have an alkyl amino group that may be cyclic one, or a salt thereof, which is useful as an active ingredient of an antiallergic agent and an antiinflammatory agent and has also an inhibitory activity against histamine release, 5-lipoxygenase inhibiting activity, relaxing activity of smooth musculus trachealis and inhibitory activity against carrageenin edema, and further, is useful as medicine for prevention and treatment of bronchial asthma, allergic coryza, allergic conjunctivitis, urticaria, atopic dermatitis, other inflammatory diseases or the like.

Kaken Pharmaceutical Co., Ltd.

Azaazulene compounds which are useful as antiallergic and antiinflammatory agents

urticaria

tūska

edema

urticaria/tūska

Method for preventing or treating an allergic disease using extract from illicium verum

Azaazulene compounds which are useful as antiallergic and antiinflammatory agents

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