Amarogentin as topical anticancer and anti-infective potential: Scope of lipid based vesicular in its effective delivery.

There is the need of development of liposomes based nanomedicines formulation for the better efficacy and safety of the available drugs in the market. Liposomes have various applications in the field of pharmaceutical and medical field for their drug target potential, diagnostic importance and imaging techniques. Natural plant based drugs and their derivative have been used in the medicine, nutraceuticals, perfumery, cosmetic and beverages industry. More than half of the prescribed drugs in the worldwide are mainly derived from different natural sources. Development of plant derived product is an emerging field of food, pharmaceutical and health industries. Plants belonging to Gentianaecae family are well known for their bitter taste and Swertia chirata is one of best plant among them. Various active phytochemical of Swertia chirata are bitter secoiridoids like gentiopicroside, amarogentin, swertiamarin, isovitexin and isogentisin. Peoples are using different species of Swertia in the form of decoction, infusion, paste and juice for the treatment of fever and enteric diseases. Swertia chirata possess anticarcinogenic, antioxidative, hypoglycemic, antihepatotoxic, antimalarial, anti-inflammatory and antimicrobial activities. Amarogentin is a bitter secoiridoid glycoside present in Swertia chirata plant is an activator of human bitter taste receptor. Pharmacologically amarogentin is having antibacterial, antihepatitis, anticholinergic and chemopreventive activities, moreover amarogentin has been proven for their anti-lieshmanial activity. Other studies also suggested that amarogentin act against liver carcinogenesis, skin carcinogenesis and reduced tumour progression. In the present review, we have collected and compiled the data's regarding biological sources, ethnomedicinal uses, phytochemistry, anticancer and anti-infective potential of amarogentin. For better understanding of various aspects of amarogentin we have also discussed Swertia chirayita in very concise manner. Further data related to various patents on amarogentin were also discussed in this manuscript. However we also admit that new advance biological research will also increase the medicinal and pharmacological value of amarogentin. Information regarding the chemistry of amarogentin, its biological sources, bioavailability as a pharmacological agent for the treatment and management of skin disorders and various forms of cancers will be beneficial to the scientist of the medicinal field.