Recent advances in studies on cardiac structure and metabolism 1975
Measurement of extracellular fluid after acute myocardial infarction.
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The volume of distribution of [60Co]EDTA in normal dog myocardium is slightly less than that calculated from tissue contents of H2O, Cl, K, and their extracellular fluid (ECF) concentrations subsuming a steady state across cell membranes. The volume of distribution of [3H-]sorbitol was substantially higher than the measured CoEDTA space. [60Co]EDTA can be measured in ischemic myocardium that remains perfused. Extraction of [60Co]EDTA and [3H-]sorbitol is incomplete from dried biopsies.
