actinomycin d/edema

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Effects of thiourea on pulmonary edema, pleural and peritoneal effusions and toxicity in rats pretreated with actinomycin D.

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Lipopolysaccharide-induced desensitization to pancreatic edema formation in rat cerulein pancreatitis.

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Previously we reported that prior administration of lipopolysaccharide (LPS) mitigates subsequently produced cerulein (Cn) pancreatitis. To clarify the mechanism further, the pathological features of Cn pancreatitis were examined in detail after treating rats with very low doses of LPS. LPS

Kasabach-Merritt syndrome-associated kaposiform hemangioendothelioma successfully treated with cyclophosphamide, vincristine, and actinomycin D.

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OBJECTIVE The authors introduced a successful trial of a chemotherapy regimen to treat refractory thrombocytopenia and pain caused by a rare kaposiform hemangioendothelioma that had been refractory to corticosteroids. METHODS A 6-year-old Latina girl with diffuse petechiae, constant pain and edema

Factors predictive of acute regional toxicity after isolated limb infusion with melphalan and actinomycin D in melanoma patients.

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BACKGROUND Isolated limb infusion (ILI) with cytotoxic drugs is a low-flow isolated limb perfusion (ILP) performed via percutaneous catheters without oxygenation to treat metastatic melanoma confined to a limb. Response rates and duration of response following ILI are similar to those after ILP.

Protection with cycloheximide or emetine against pulmonary edema induced by ozone or nitrogen dioxide.

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Pretreatment with cycloheximide or emetine provided significant protection against pulmonary edema in rats exposed to ozone or nitrogen dioxide. Other inhibitors of protein-synthesis, actinomycin D or puromycin, failed to show such effects. Possible actions of these agents as well as the doses and

Isolated limb infusion with melphalan and actinomycin D for melanoma: a systematic review.

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Isolated limb infusion (ILI) was developed as a simplified and minimally invasive alternative to isolated limb perfusion (ILP) to treat unresectable limb melanoma. A number of centers around the world have reported their results using this procedure. In this study a systematic review of reported ILI

Efficacy of repeat isolated limb infusion with melphalan and actinomycin D for recurrent melanoma.

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BACKGROUND : Isolated limb infusion (ILI) is an effective and minimally invasive treatment option for delivering regional chemotherapy in patients with metastatic melanoma confined to a limb. Recurrent or progressive disease after an ILI, however, presents a challenge for further treatment. The

Actinomycin D suppresses the protective effect of dexamethasone in rats affected by global cerebral ischemia.

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Simultaneous occlusion of both common carotid arteries in female Sprague-Dawley CFY rats produced characteristic symptoms of global cerebral ischemia, such as staggering, circling, convulsions, followed by coma and death. A close correlation existed among these symptoms and the elevation of water

Vasogenic brain edema induced by arachidonic acid: role of extracellular arachidonic acid in blood-brain barrier dysfunction.

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The effects of free arachidonic acid on the capillary permeability of normal rat brains were studied by measuring the regional uptake of [14C]aminoisobutyric acid by a quantitative autoradiographic technique. Intracerebral infusion of sodium arachidonate increased capillary permeability in a

An effect of corticosteroids on thymocytes not mediated by macromolecule synthesis.

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Rat thymocytes were incubated for 2 min at 37 degrees C and the cells then broken by osmotic shock in 1.5 mM MgCl2 and the nuclei harvested. Treatment with 50 nM dexamethasone for 2 min resulted in about one third of nuclei showing abnormalities in appearance, in shape and density. This was not

PP120. Hydatidiform mole as a cause of eclampsia in the first trimester: A case report.

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BACKGROUND The occurrence of preeclampsia before the 20th week of gestation is rare and it has been associated with hydatidiform molar pregnancy. OBJECTIVE We describe a case of first trimester eclampsia which occurred in a patient with hydatidiform mole. METHODS Case report. RESULTS A 16-year-old

Studies on the mechanism of anti-inflammatory activities of papyriogenin a and papyriogenin C.

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The mechanism of anti-inflammatory action of papyriogenin A and C, obtained from Tetrapanax papyriferum, were investigated by the following methods; the cotton pellet granuloma test in normal and adrenalectomized rats, the blockade by anti-glucocorticoids of vascular permeability caused by serotonin

An in vitro cell model system for the study of the effects of ozone and other gaseous agents on phagocytic cells.

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Ozone (O(3)), a major component of air pollution and a very strong oxidizing agent, can lead to lung injury associated with edema, inflammation, and epithelial cell damage. The ozone effects on pulmonary immune cells have been studied by various in vivo and in vitro systems. In this report, we

[Possible mechanisms of the anti-inflammatory action of polyamines].

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Carrageenin paw edema of rats was inhibited in a dose-dependent manner by subcutaneous administration of polyamines. The latter had to be administered at least 2 hr before carrageenin challenge to achieve such inhibition. Moreover, inhibition was blocked by the simultaneous injection of actinomycin

Delayed anti-inflammatory action of nedocromil sodium in the rat paw is dependent on de novo protein synthesis.

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Nedocromil sodium is commonly suggested to reduce allergic inflammation by inhibiting mediator release from mast cells. However, nedocromil also exhibits a wide range of additional anti-inflammatory activities, including inhibition of increased vascular permeability induced by individual mediators

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