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Страница 1 од 21 резултати
Disseminated mucocutaneous herpes simplex type 2 infection in a renal transplant recipient: response to adenine arabinoside (Vidarabine).
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A 27-year-old woman with a well-functioning cadaveric renal transplant presented with recurrent mucocutaneous herpes simples type two infection associated with a severe systemic illness. Two courses of treatment with adenine arabinoside (Vidarabine) were associated with rapid healing of the herpetic
Toxicity of adenine arabinoside in humans.
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Six forms of reversible adverse reactions to adenine arabinoside (vidarabine) were observed in a two-year period among 42 patients (19 of whom had lymphomas, leukemias, or other malignancies) who were treated for complicated infections with varicella-zoster or herpes simplex virus. Six patients
A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer.
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OBJECTIVE
Methylthioadenosine phosphorylase (MTAP)-deficient tumors are dependent on the de novo purine synthesis pathway. These cancers are potential targets for selective chemotherapy with inhibitors of de novo adenine synthesis such as L-alanosine [L-2-amino-3-(N-hydroxy-N-nitrosamino) propionic
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor.
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BACKGROUND
FK866 is a potent inhibitor or NAD synthesis. This first-in-human study was performed to determine the maximum-tolerated dose, toxicity profile, and pharmacokinetics on a 96-h continuous infusion schedule.
METHODS
Twenty four patients with advanced solid tumor malignancies refractory to
Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.
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OBJECTIVE
Gastroparesis is a complication of diabetes characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and
Drug-induced methaemoglobinaemia. Treatment issues.
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In normal erythrocytes, small quantities of methaemoglobin are formed constantly and are continuously reduced, almost entirely by the reduced nicotine adenine dinucleotide (NADH) diaphorase system, rather than the reduced nicotine adenine dinucleotide phosphate (NADPH) diaphorase system.
Mechanistic Aspects of Fungicide-Induced DNA Damage: Spectroscopic and Molecular Dynamics Simulation Studies.
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The non-targeted action of fungicides leads to DNA damage of organisms, which causes several serious diseases such as cancer, behavioral change, and nausea. The mechanistic aspects of DNA damage by fungicides are not much known, irrespective of its importance. Spectroscopic and molecular dynamics
Clinical experience with fludarabine and its immunosuppressive effects in pretreated chronic lymphocytic leukemias and low-grade lymphomas.
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Fludarabine monophosphate (FAMP) is a new adenine nucleoside analogue with a promising efficacy in B-cell chronic lymphocytic leukemia (B-CLL) and low-grade non-Hodgkin lymphomas (NHLs). Here, the clinical experience and side effects with FAMP are reported in 77 patients with pretreated CLL (59
Role of fludarabine as monotherapy in the treatment of chronic lymphocytic leukemia.
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Fludarabine is a synthetic adenine nucleoside analog that is indicated for first- and second-line treatment of chronic lymphocytic leukemia (CLL). The recommended intravenous (i.v.) dosage regimen is 25 mg/m2 daily for 5 consecutive days, with treatment cycles repeated every 28 days. In
Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia.
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BACKGROUND
Fludarabine monophosphate is a new adenine nucleoside analogue with a promising efficacy in B-cell chronic lymphocytic leukemia (B-CLL) with response rates, including hematological complete remissions, of 50%-60% in previously treated and 75%-80% in previously untreated
Mutation in the Prothrombin Gene G20210A as a Cause of Cerebral Venous Thrombosis.
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Introduction. Cerebral venous sinus thrombosis (CVST) is a rare form of cerebrovascular disease, which may manifest clinically by a wide variety of signs and symptoms. It has been associated with multiple risk factors including genetic or acquired blood disorders, infections, and trauma. Case
Phase I trial of intravenous thymidine and carboplatin in patients with advanced cancer.
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OBJECTIVE
To evaluate the biologic interactions and toxicities of carboplatin combined with a 24-hour infusion of thymidine 75 mg/m(2) in a phase I trial.
METHODS
Thirty-two patients with cancer refractory to conventional therapy were treated. The first set of patients (n = 7) received thymidine
Fludarabine: a review.
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The new fluorinated adenine analog, fludarabine, has been tested for efficacy in many tumor types over the past ten years. Two other similar nucleoside analogs are currently available for commercial use. Cytarabine is used principally as an antileukemic agent, and vidarabine as an antiviral. Unlike
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data.
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OBJECTIVE
Depletion of cellular nicotinamide adenine dinucleotide (NAD) by inhibition of its synthesis is a new pharmacological principle for cancer treatment currently in early phases of clinical development. We present new and previously published data on the safety and efficacy of these drugs
Treatment of cutaneous T cell lymphoma with 2'-deoxycoformycin (pentostatin).
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2'-Deoxycoformycin, a potent inhibitor of adenosine deaminase, was administered to three patients with cutaneous T cell lymphoma refractory to multiple treatment modalities. Patient 1, who received 5 mg/m2/day for 3 days at 35- to 71-day intervals, has achieved a complete remission greater than 16
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